长链非编码RNA DANCR在甲状腺癌中的研究进展  

Progress of long non-coding RNA DANCR in thyroid cancer

作　　者：钟莉莉[1] 程远娟[2] 马静茹[3] 赵银龙[4] Zhong Lili;Cheng Yuanjuan;Ma Jingru;Zhao Yinlong(Jilin Provincial Key Laboratory on Molecular and Chemical Genetic,Research Center,the Second Hospital of Jilin University,Changchun 130041,China;Department of Nursing,the Second Hospital of Jilin University,Changchun 130041,China;Department of Clinical Laboratory,the Second Hospital of Jilin University,Changchun 130041,China;Department of Nuclear Medicine,the Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林省重大疾病分子与化学遗传学重点实验室,吉林大学第二医院研究中心,长春130041 [2]吉林大学第二医院护理部,长春130041 [3]吉林大学第二医院检验科,长春130041 [4]吉林大学第二医院核医学科,长春130041

出　　处：《肿瘤研究与临床》2021年第4期314-317,共4页Cancer Research and Clinic

基　　金：吉林省科技厅科技发展计划(20180101101JC);吉林省财政厅卫生专项(3D518V613429);吉林省医疗卫生人才专项(2019SCZT026、2020SCZT061);白求恩计划(419161900018)。

摘　　要：甲状腺癌是最常见的头颈部恶性肿瘤,发病率呈逐年上升趋势。因此探究甲状腺癌的发生、发展机制,开发甲状腺癌诊断标志物和治疗靶点,对提高甲状腺癌的疗效、延长患者生存时间具有重要意义。前期研究中发现长链非编码RNA(lncRNA)DANCR在甲状腺癌中异常高表达,可通过影响miRNA-185-5p及转录因子SMARCB1来促进富含亮氨酸重复序列激酶2(LRRK2)的表达,间接参与细胞自噬而调控甲状腺癌的发展,有望成为甲状腺癌诊断及治疗的新靶点。文章就lncRNA DANCR在甲状腺癌中的调控机制进行介绍,为甲状腺癌的基础研究和临床诊疗提供新思路。Thyroid cancer is the most common head and neck malignant tumor,and its incidence is increasing year by year.Therefore,it is of great significance to explore the mechanism of the occurrence and development of thyroid cancer,and develop the diagnostic markers and therapeutic targets of thyroid cancer,so as to improve the curative effect of thyroid cancer and prolong the survival time of patients.The previous study has found that long non-coding RNA(lncRNA)DANCR has abnormal high expression in thyroid cancer,which could promote the expression of leucine-rich repeat kinase 2(LRRK2)by affecting miRNA-185-5p and transcription factor SMARCB1,and indirectly participate in autophagy and regulate the development of thyroid cancer.LncRNA DANCR is expected to become a new target for diagnosis and treatment of thyroid cancer.This paper introduces the possible regulatory mechanism of lncRNA DANCR in thyroid cancer,and provides new ideas for the basic research and clinical diagnosis and treatment of thyroid cancer.

关 键 词：甲状腺肿瘤 长链非编码RNA 富含亮氨酸重复序列激酶2 miRNA-185-5p 

分 类 号：R736.1[医药卫生—肿瘤]