德阳地区524例食物不耐受患者食物特异性抗体检测结果分析  

Analysis of the detection results of food-specific antibodies in 524 patients with food intolerance in Deyang area

作　　者：鄂建飞[1] 刘利洪[1] 徐开渝[1] 曾燕[1] 詹璐[1] E Jian-fei;LIU Li-hong;XU Kai-yu;ZENG Yan;ZHAN Lu(People's Hospital of Deyang,Deyang,Sichuan 618000,China)

机构地区：[1]德阳市人民医院,四川618000

出　　处：《应用预防医学》2021年第2期106-109,共4页Applied Preventive Medicine

基　　金：德阳市科技局重点研发项目(2018SZS076)。

摘　　要：目的探索德阳地区儿童食物不耐受患者食物特异性抗体阳性情况,为预防和治疗食物不耐受提供参考。方法观察分析食物不耐受患儿临床表现,采用ELISA法检测食物不耐受患儿血清食物过敏原特异性IgG。结果共选取食物不耐受患儿524例,其临床症状分布为消化系统171例(32.6%)、皮肤系统120例(22.9%),呼吸系统93例(17.7%)、神经系统75例(14.3%)、营养不良35例(6.7%)。所选取患儿中,食物特异性IgG检测阳性者427例,阳性率为81.5%(427/524)。食物特异性IgG阳性率前3位分别是牛奶(60.2%)、鸡蛋(57.4%)和小麦(20.8%)。4个年龄组间,婴儿组牛奶IgG阳性率最高(56.7%),幼儿组鸡蛋IgG阳性率最高(97.6%),学龄前组牛奶IgG阳性率最高(63.5%),学龄组牛奶IgG阳性率最高(30.3%)。婴儿组和幼儿组、婴儿组和学龄组、幼儿组和学龄前组、幼儿组和学龄组、学龄前组和学龄组的牛奶、鸡蛋特异性IgG阳性率比较,差异均有统计学意义(P值均<0.05);婴儿组和学龄前组的牛奶、鸡蛋特异性IgG阳性率比较,差异均无统计学意义(P值均> 0.05);婴儿组和幼儿组、幼儿组和学龄组、学龄前组和学龄组的小麦IgG阳性率比较,差异均有统计学意义(P值均<0.05)。结论食物不耐受患儿主要临床表现为消化系统、皮肤系统和呼吸系统症状。牛奶、鸡蛋和小麦是该地区儿童食物不耐受最常见的致敏源。结合食物不耐受患儿的食物抗体血清学检测以及该地区各年龄阶段儿童不耐受食物特点,对患儿膳食进行科学调整,可以帮助患儿改善临床症状。Objective To explore the positive status of food-specific antibodies in patients with children,s food intolerance in Deyang area, providing references for the prevention and treatment of food intolerance.Methods The clinical manifestations of children with food intolerance were observed and analyzed. The serum food allergen-specific IgG of children with food intolerance was detected by ELISA.Results A total of 524 children with food intolerance were selected. The distribution of clinical symptoms were 171 cases(32.6%) of digestive system, 120 cases(22.9%) of skin symptoms, 93 cases(17.7%) of respiratory system symptoms, 75 cases(14.3%) of neurological symptoms, and 35 cases of malnutrition(6.7%). Among the selected children, 427 were tested positive for food allergen-specific IgG, and the positive rate was 81.5% (427/524). The top three food allergen-specific IgG positive rates were milk(60.2%), eggs(57.4%)and wheat(20.8%). Among the four age groups, the infant group had the highest milk IgG positive rate of 56.7%, the toddler group had the highest egg IgG positive rate of 97.6%, the preschool group had the highest milk IgG positive rate of 63.5%, and the school-age group had the highest milk IgG positive rate of 30.3%. The difference in milk and egg specific IgG positive rates of the infant group and toddler group, infant group and school age group, toddler group and preschool group, toddler group and school age group, and preschool group and school age group were statistically significant(all P values<0.05). There was no significant difference in the positive rate of milk and egg-specific IgG between the infant group and the preschool group(all P values>0.05). The difference in the positive rate of wheat IgG between infant group and toddler group, toddler group and school-age group, preschool group and school-age group was statistically significant(all P values<0.05). Conclusion The main clinical manifestations of children with food intolerance are symptoms in digestive system, skin system and respiratory syste

关 键 词：食物不耐受 食物特异性IGG 系统疾病 自身抗体 

分 类 号：R151.3[医药卫生—营养与食品卫生学]