基于电化学传感器检测赭曲霉毒素A的研究进展  

Research Advance in Detection of Ochratoxin A Based on Electrochemical Sensors

作　　者：李林芝 何赛君 黄添增 刘星[1,3,4,5] 陈奇 陈健[1,3,4,5] 曹宏梅 LI Lin-zhi;HE Sai-jun;HUANG Tian-zeng;LIU Xing;CHEN Qi;CHEN Jian;CAO Hong-mei(College of Food Science and Technology,Hainan University,Haikou 570228,China;College of Chemistry and Engineering Technology,Hainan University,Haikou 570228,China;Key Laboratory of Food Nutrition and Functional Food of Hainan Province,Haikou 570228,China;Engineering Research Center of Utilization of Tropical Polysaccharide Resources,Haikou 570228,China;Hainan Provincial Engineering Research Center of Aquatic Resources Efficient Utilization in the South China Sea,Haikou 570228,China)

机构地区：[1]海南大学食品科学与工程学院,海南海口570228 [2]海南大学化学与工程技术学院,海南海口570228 [3]海南省食品营养与功能食品重点实验室,海南海口570228 [4]热带多糖资源利用教育部工程研究中心,海南海口570228 [5]海南省南海水产资源高效利用工程研究中心,海南海口570228

出　　处：《分析测试学报》2021年第5期639-647,共9页Journal of Instrumental Analysis

基　　金：海南省高层次人才项目(2019RC129);海南大学科研启动基金(KYQD(ZR)1939,KYQD(ZR)1952)。

摘　　要：赭曲霉毒素A(Ochratoxin A,OTA)是一种由赭曲霉、青霉菌等真菌产生的次级代谢产物,在自然界分布广泛,具有肝毒性、肾毒性、致癌、致突变作用。鉴于其危害的严重性和污染的广泛性,发展高灵敏度的OTA检测技术引起了研究者的广泛关注。该文阐述了近年来新型电化学传感技术在OTA检测方面的发展及应用,全面综述了目前OTA电化学传感器的主要类型及其优缺点,并对其发展方向提出了展望,从而为基于OTA的电化学传感器的深入研究与应用提供了参考。Ochratoxin A(OTA)is a secondary metabolite originated from fungi penicillium and aspergillus,which is widely distributed in nature,with various strong toxicities such as hepatotoxicity,nephrotoxicity,carcinogenic and mutagenic effects.Considering these potential toxic effects of OTA,the International Agency for Research on Cancer(IARC)has classified it as a human carcinogen(ⅡB).Therefore,how to develop OTA detection methods with high sensitivity have arouse wide attention.The development and applications of electrochemical sensors for OTA detection for the past 10 years are summarized in this paper.Based on different identification elements,the main types of OTA electrochemical sensors,adaptor and immune sensing,and the advantages and disadvantages of the corresponding sensings are described.The prospect for the future development of OTA electrochemical sensors is put forward.This review provides a certain reference for the further research and application of OTA electrochemical sensors.

关 键 词：赭曲霉毒素A(OTA) 电化学传感 研究进展 

分 类 号：O657.1[理学—分析化学] S852.44[理学—化学]