认知衰弱诊治的研究进展  

Progress in the diagnosis and treatment of cognitive frailty

作　　者：赵瑞雪[1] 马雅军 刘惠[1] 李晓东[1] 王笑峰 蒋晓燕 李淑娟[1] ZHAO Rui-xue;MA Ya-jun;LIU Hui;LI Xiao-dong;WANG Xiao-feng;JIANG Xiao-yan;LI Shu-juan(Department of Neurology,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100020;Ministry of Education Key Laboratory of Contemporary Anthropology,Human Phenome Institute,Fudan University,Shanghai 200433;Department of Pathology and Pathophysiology,Tongji University School of Medicine,Shanghai 200092,China)

机构地区：[1]首都医科大学附属北京朝阳医院神经内科,北京100020 [2]复旦大学人类表型组研究院现代人类学教育部重点实验室,上海200433 [3]同济大学医学院病理学与病理生理学系,上海200092

出　　处：《基础医学与临床》2021年第6期895-898,共4页Basic and Clinical Medicine

基　　金：国家重点研发计划项目(2018YFC2000400,2018YFC2002000);国家自然科学基金(81971102)。

摘　　要：认知衰弱是一种同时存在身体衰弱和认知损害而使痴呆风险增加的老年综合征,与功能性残疾、住院、跌倒和全因死亡等不良健康事件及痴呆、血管性痴呆、神经认知障碍的发生相关,具有潜在的可逆性。未来制定明确统一的认知衰弱操作性定义,对于早期识别、干预认知衰弱,以及痴呆早期或无症状阶段的二级预防具有重要意义。Cognitive frailty,which increases the risk of dementia,is a geriatric syndrome characterized by both physical frailty and cognitive impairment.It is associated with adverse health events such as functional disability,hospitalization,falls,all-cause mortality and the incidence of dementia,vascular dementia,neurocognitive disorders,with potential reversibility.A clear and unified operational definition of cognitive frailty in the future is of great significance for early recognition and intervention of cognitive frailty and secondary prevention of early or asymptomatic dementia.

关 键 词：认知衰弱 身体衰弱 认知障碍 衰弱模型 不良健康事件 

分 类 号：R741[医药卫生—神经病学与精神病学]