单纯腹腔游离癌细胞阳性胃癌的研究进展  

Progress in gastric cancer with positive peritoneal cytology

作　　者：李百隆 苗儒林[1] 李子禹[1] Li Bailong;Miao Rulin;Li Ziyu(Center of Gastrointestinal Tumors,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Peking University Cancer Hospital&Institute,Beijing 100142,China)

机构地区：[1]北京大学肿瘤医院胃肠肿瘤中心,北京市肿瘤防治研究所,恶性肿瘤发病机制及转化研究教育部重点实验室,100142

出　　处：《中华胃肠外科杂志》2021年第5期458-462,共5页Chinese Journal of Gastrointestinal Surgery

摘　　要：单纯腹腔游离癌细胞阳性胃癌是目前胃癌研究的热点,其预后较差。腹腔游离癌细胞可能是在癌细胞迁移、侵袭和转移过程中形成的。研究显示,胃癌T分期、腹膜转移、淋巴结转移、组织学低分化、革囊胃、食管胃结合部癌以及手术操作等是腹腔游离癌细胞阳性胃癌的临床病理危险因素。目前,腹腔游离癌细胞的获取主要通过诊断性腹腔镜联合腹腔灌洗,细胞病理学检测被认为是其诊断的金标准。其治疗策略国内外目前尚不完全一致,包括术前化疗联合胃癌根治性切除、手术后化疗、腹腔内局部治疗等,均可延长患者生存期。现阶段我国多采用手术后化疗的治疗策略,最佳治疗方案有待进一步研究。Gastric cancer with positive peritoneal cytology is a hotspot in the study of gastric cancer,and its prognosis is poor.Intraperitoneal free cancer cells may be associated with cancer cells migration,invasion and metastasis.Tumor T stage,peritoneal metastasis,lymph node metastasis,low histological differentiation,linitis plastica,adenocarcinoma of esophagogastric junction,and operation are the clinicopathological risk factors of gastric cancer with positive peritoneal cytology.Currently,the acquisition of free cancer cells is mainly through diagnostic laparoscopy combined with peritoneal lavage,and cytopathological examination is gold standard for diagnosis.Its treatment strategies are not in consensus,including preoperative chemotherapy combined with radical resection,postoperative chemotherapy and peritoneal local treatment,which can prolong the survival of patients.At present,postoperative chemotherapy is often used in China,and the best treatment strategies remain to be further studied.

关 键 词：胃肿瘤 单纯腹腔游离癌细胞阳性胃癌 机制 检测 治疗 

分 类 号：R735.2[医药卫生—肿瘤]