原发性腮腺平滑肌肉瘤临床病理分析  

Clinicopathological Analysis of Primary Leiomyosarcoma of Parotid Gland

作　　者：余方[1,2] 陈琼荣[1,2] 向远航 徐剑 YU Fang;CHEN Qiongrong;XIANG Yuanhang;XU Jian(Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;Center for Pathology and Molecular Diagnostics, Wuhan University, Wuhan 430071, China)

机构地区：[1]武汉大学中南医院病理科,湖北武汉430071 [2]武汉大学病理中心,湖北武汉430071

出　　处：《口腔医学研究》2021年第6期519-522,共4页Journal of Oral Science Research

摘　　要：目的:探讨原发性腮腺平滑肌肉瘤(leiomyosarcoma,LMS)的临床病理特征及其鉴别诊断要点。方法:对两例原发性腮腺LMS进行临床病理观察和免疫组化结果分析,并对该疾病的相关文献进行复习。结果:2例男性患者腮腺区肿块,镜下肿瘤细胞均呈长梭形平行或交织条束状排列,侵及周围组织;免疫组化结果显示肿瘤细胞表达SMA、Caldesmon。两例患者均接受手术及术后放射治疗,随访两年未见复发及远处转移。结论:原发性腮腺LMS是颌面部罕见恶性肿瘤,术前诊断较为困难,免疫组织化学有助于该疾病的诊断。Objective:To investigate the clinicopathological features and differential diagnosis of primary leiomyosarcoma(LMS)of parotid gland.Methods:Two cases of primary parotid LMS were observed clinicopathologically and analyzed immunohistochemically,and the related literatures were reviewed.Results:Two male patients presented with parotid masses.Pathologic findings revealed that the sarcoma was composed of tumor cells arranged in a long spindle shape,parallel or interwoven bundles,and invaded the surrounding tissues.The immunohistochemical results showed that the tumor cells expressed SMA and Caldesmon.Two patients received surgery and radiotherapy and were followed up for two years without recurrence or distant metastasis.Conclusion:Primary parotid gland LMS was a rare malignant tumor in the maxillofacial region,which was difficult to be diagnosed preoperatively.Immunohistochemistry was helpful to the diagnosis of this disease.

关 键 词：腮腺 平滑肌肉瘤 免疫组织化学 

分 类 号：R73[医药卫生—肿瘤]