稳定期精神分裂症患者血浆白介素-1β水平及其与症状关系  

Level of interleukin-1βand its relationship with symptoms in stable patients with schizophrenia

作　　者：冯薇[1] 贾强 谭淑平[1] 李佳[1] 王志仁[1] 黄隽超 谭云龙[1] FENG Wei;JIA Qiang;TAN Shu-ping;LI Jia;WANG Zhi-ren;HUANG Jun-chao;TAN Yun-long(Beijing Huilongguan Hospital,Beijing 100096,China)

机构地区：[1]北京大学回龙观临床医学院,北京回龙观医院,100096

出　　处：《临床精神医学杂志》2021年第3期173-176,共4页Journal of Clinical Psychiatry

基　　金：北京市医管局临床技术创新项目(XMLX201513);国家自然科学基金国际(地区)合作项目(中芬)(81461130016)。

摘　　要：目的:探讨稳定期精神分裂症患者血浆白介素-1β(IL-1β)水平及其与临床症状的关系。方法:纳入稳定期精神分裂症患者75例(患者组)和健康对照者40名(对照组),采用流式多重蛋白分析技术检测血浆炎症因子IL-1β的浓度,采用阳性与阴性症状量表(PANSS)评定患者临床症状。结果:患者组IL-1β水平[(2.10±0.59)pg/ml]较对照组[(1.90±0.28)pg/ml]高(P<0.05);不同性别、是否吸烟、是否有精神疾病家族史患者之间血浆IL-1β水平差异无统计学意义(P均>0.05);患者组血浆IL-1β水平与性别、年龄、受教育年限、首次发病年龄、首次住院年龄、总病程、用药剂量(折合氯丙嗪等效剂量)无相关(P均>0.05)。患者组血浆IL-1β水平与PANSS中反应缺乏因子(r=-0.24,P=0.05)、偏执性因子(r=-0.36,P=0.00)、激活因子(r=-0.29,P=0.02)呈负相关。结论:稳定期精神分裂症患者血浆IL-1β浓度高于健康对照者,其与临床症状严重程度存在一定联系。Objective:To explore the level of plasma interleukin-1β(IL-1β)in stable schizophrenic patients,and its relationship with clinical symptoms.Method:75 patients with stable schizophrenia(patient group)and 40 healthy controls(control group)were enrolled.The levels of plasma IL-1βwere detected by flow multiplex protein analysis.The clinical symptoms of patients were assessed by Positive and Negative Symptom Scale(PANSS).Results:The level of plasma interleukin-1β[(2.10±0.59)pg/mL]in the patient group was higher than that in the control group[(1.90±0.28)pg/mL](P<0.05).There were no significant differences in plasma IL-1βlevels of patients with different gender,smoking or family history of mental illness(all P>0.05).The level of plasma IL-1βin the patient group had no correlation with gender,age,education years,age of first onset,age of first hospitalization,total course of illness,drug dose(all P>0.05).The level of IL-1βwas negatively correlated with reaction deficiency factor(r=-0.24,P=0.05),paranoid factor(r=-0.36,P=0.00),activator factor(r=-0.29,P=0.02).Conclusion:The patients with stable schizophrenia have higher plasma level of IL-1βthan healthy controls,which exists a certain relationship with the severity of clinical symptoms.

关 键 词：精神分裂症 临床症状 白介素-1Β 

分 类 号：R749.3[医药卫生—神经病学与精神病学]