The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2  

作　　者：Cheng Li Xiaolong Tian Xiaodong Jia Jinkai Wan Lu Lu Shibo Jiang Fei Lan Yinying Lu Yanling Wu Tianlei Ying 

机构地区：[1]MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology,School of Basic Medical Sciences,Shanghai Medical College,Fudan University,Shanghai,China [2]Department of Comprehensive Liver Cancer,The Fifth Medical Center,Chinese PLA General Hospital,Beijing,China [3]Shanghai Key Laboratory of Medical Epigenetics,International Co-laboratory of Medical Epigenetics and Metabolism,Ministry of Science and Technology,Institutes of Biomedical Sciences,Fudan University,Shanghai,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第4期1116-1118,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants from the National Key R&D Program of China(2019YFA0904400);National Natural Science Foundation of China(81822027,81630090);National Megaprojects of China for Major Infectious Diseases(2018ZX10301403,2018ZX10101003);the staff from Core Facility of Microbiology and Parasitology,Shanghai Medical College,Fudan University.

摘　　要：Dear Editor,The ongoing COVID-19 pandemic has resulted in over 25.0 million confirmed cases and over 840,000 deaths globally.As the third severe respiratory disease outbreak caused by the coronavirus,COVID-19 has led to much larger infected populations and coverage of geographic areas than SARS and MERS.Such high prevalence of infection has raised significant concerns about the emergence and spread of escape variants,which may evade human immunity and eventually render candidate vaccines and antibody-based therapeutics ineffective.Indeed,some naturally mutated SARS-CoV or MERS-CoV strains from the sequential outbreaks were reported to resist neutralization by the antibodies isolated during the first outbreak1,2.

关 键 词：IMMUNITY eventually RENDER 

分 类 号：R373[医药卫生—病原生物学]