宫颈鳞癌酰胺质子转移加权成像与Ki-67表达的相关性研究  

Amide proton transfer-weighted MRI of cervical squamous carcinoma:correlation with Ki-67 proliferation status

作　　者：何泳蓝[1] 林澄昱 戚亚菲 王小奇 周海龙[1] 李源[3] 陈博[4] 向阳[3] 薛华丹[1] 金征宇[1] He Yonglan;Lin Chengyu;Qi Yafei;Wang Xiaoqi;Zhou Hailong;Li Yuan;Chen Bo;Xiang Yang;Xue Huadan;Jin Zhengyu(Department of Radiology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China;Oncology Section,Philips Healthcare,Beijing 100600,China;Department of Gynaecology and Obstetrics,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Pathology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放射科,100730 [2]飞利浦(中国)投资有限公司肿瘤事业部,北京100600 [3]中国医学科学院北京协和医学院北京协和医院妇产科,100730 [4]中国医学科学院北京协和医学院北京协和医院病理科,100730

出　　处：《中华放射学杂志》2021年第5期517-521,共5页Chinese Journal of Radiology

基　　金：国家自然科学基金青年项目(81901829);中央高校基本科研业务费青年教师项目(3332019032)。

摘　　要：目的探讨基于宫颈鳞癌酰胺质子转移加权(APTw)成像测量的APTw值及其与Ki-67表达水平的相关性。方法前瞻性纳入2017年10月至2018年12月北京协和医院24例宫颈鳞癌患者,均为国际妇产科联盟(FIGO)Ⅰ~Ⅲ期,于3.0 T MR扫描仪行盆腔形态学MRI、三维快速自旋回波APTw和DWI成像。由2名放射科医师独立测量病灶最长径、病灶最大层面的APTw值和ADC值。计算观察者间ICC以评估测量一致性。由1名病理科医师评估病灶Ki-67标记指数。应用Pearson相关性分析评估宫颈鳞癌病灶APTw值、最长径、ADC值与Ki-67标记指数的相关性。结果宫颈鳞癌的APTw值为(2.9±0.5)%,观察者间测量一致性良好(ICC=0.972,95%CI 0.937~0.988)。宫颈鳞癌APTw值与Ki-67标记指数[(61.9±18.7)%]呈中度正相关(r=0.532,P=0.008)。宫颈鳞癌病灶最长径为(28.7±10.6)mm,ADC值为(0.998±0.217)×10^(-3) mm^(2)/s,与Ki-67标记指数均无明显相关性(r=0.038、P=0.859,r=0.238、P=0.263)。结论APTw值可以在一定程度上反映宫颈鳞癌的增殖活性。Objective To investigate the correlation between amide proton transfer-weighted(APTw)values and Ki-67 labeling index of cervical squamous cell carcinoma.Methods From October 2017 to December 2018,24 patients with cervical squamous cell carcinoma[International Federation of Gynecology and Obstetrics(FIGO)stageⅠ-Ⅲ]were prospectively enrolled in Peking Union Medical College Hospital and underwent pelvic morphological MRI on a 3.0 T MR scanner,including three-dimensional turbo-spin-echo APTw imaging and DWI.The maximum diameters of the lesions,APTw values and ADC values on the slice with the maximum diameter of the lesion were independently measured by two radiologists.The ICC was computed to evaluate the inter-observer consistency.Ki-67 immunohistochemical expression status was assessed by one pathologist.The Pearson correlation analysis was performed between the APTw values,maximum diameters,ADC values and Ki-67 labeling index.Results The APTw values of cervical squamous cell carcinoma were(2.9±0.5)%.Inter-observer ICC was 0.972(95%CI 0.937-0.988).The APTw values were positively moderately correlated with Ki-67 labeling index[(61.9±18.7)%,r=0.532,P=0.008].The maximum diameters of the lesions were(28.7±10.6)mm.The mean ADC values were(0.998±0.217)×10^(-3) mm^(2)/s.No correlations were found between maximum diameters,ADC values and Ki-67 labeling index(r=0.038,P=0.859;r=0.238,P=0.263).Conclusion APTw values can partially reveal the proliferation status of cervical squamous cell carcinoma.

关 键 词：宫颈肿瘤 癌 鳞状细胞 磁共振成像 酰胺质子转移加权成像 

分 类 号：R737.33[医药卫生—肿瘤]