Regulation of gene expression in chickens by heat stress  

作　　者：Akshat Goel Chris Major Ncho Yang-Ho Choi 

机构地区：[1]Department of Animal Science,Gyeongsang National University,Jinju 52828,Republic of Korea [2]Division of Applied Life Sciences(BK21 Plus Program),Gyeongsang National University,Jinju 52828,Republic of Korea [3]Full list of author information is available at the end of the article

出　　处：《Journal of Animal Science and Biotechnology》2021年第2期438-450,共13页畜牧与生物技术杂志（英文版）

基　　金：supported in part by the Korea Research Fellowship Program(2019H1D3A1A01071142);through the National Research Foundation of Korea(NRF)and by the Forest Science Technology R&D Program(2020193C10-2022-BA01);provided by Korea Forest Service(Korea Forestry Promotion Institute).

摘　　要：High ambient temperatures are a critical challenge in the poultry industry which is a key producer of the animal-based food.To evaluate heat stress levels,various parameters have been used,including growth rates,blood metabolites,and hormones.The most recent advances have explored expression profiling of genes that may play vital roles under stress.A high ambient temperature adversely affects nutrient uptake and is known to modulate the expression of genes encoding for sodium-dependent glucose transporters,glucose transporters,excitatory amino acid transporters,and fatty acidbinding proteins which are responsible for the absorption of macronutrients in the intestine.Various defensive activities are stimulated to protect the cell of different tissues from the heat-generated stress,including expression of early stress response genes coding for heat shock protein(HSP),c-FOS like protein,brain-derived neurotrophic factor(BDNF),and neuronal nitric oxide synthase(nNOS);antioxidant enzyme genes such as superoxide dismutase(SOD),catalase(CAT),and nicotinamide adenine dinucleotide phosphate oxidase(NOX4);and immune-related genes such as cytokines and toll-like receptors(TLRs).The potential role of HSPs in protecting the cell from stress and their presence in several tissues make them suitable markers to be evaluated under heat stress.BDNF and c-FOS genes expressed in the hypothalamus help cells to adapt to an adverse environment.Heat causes damage to the cell by generating reactive oxygen species(ROS).The NOX4 gene is the inducer of ROS under heat stress,which is in turns controlled by antioxidant enzymes such as SOD and CAT.TLRs are responsible for protecting against pathogenic attacks arising from enhanced membrane permeability,and cytokines help in controlling the pathogen and maintaining homeostasis.Thus,the evaluation of nutrient transporters and defense mechanisms using the latest molecular biology tools has made it possible to shed light on the complex cellular mechanism of heat-stressed chickens.As the impacts of

关 键 词：ANTIOXIDANT Gene expression Heat stress IMMUNITY METABOLISM Nutrient transporter POULTRY 

分 类 号：S831[农业科学—畜牧学]