急性脑梗死患者可溶性血管内皮细胞蛋白C受体和血管性血友病因子与白介素-6及病情严重程度的相关性探讨  

Association of soluble endothelial protein C receptor and von Willebrand factor with interleukin-6 and disease severity in patients with acute cerebral infarction

作　　者：王乐[1] 杨增烨[1] 王柳毅[1] WANG Le;YANG Zeng-Ye;WANG Liu-Yi(Department of Neurology,Affiliated Hospital of Yan’an University,Yan’an,Shanxi 716000,China)

机构地区：[1]延安大学附属医院神经内科,陕西延安716000

出　　处：《国际神经病学神经外科学杂志》2021年第2期126-129,共4页Journal of International Neurology and Neurosurgery

摘　　要：目的探讨急性脑梗死(ACI)患者病情严重程度评估中可溶性血管内皮细胞蛋白C受体(sEPCR)和血管性血友病因子(vWF)的价值以及两者与白介素-6(IL-6)的相关性。方法选取延安大学附属医院神经内科2017年1月—2019年1月收治的ACI患者125例(A组),另选取同期该院健康体检者103例(B组)。按ACI病情严重程度将A组分成3组,即轻度组(63例)、中度组(39例)和重度组(23例)。分析两组血清sEPCR、vWF在ACI病情诊断与预后评估中的价值以及两者与IL-6的相关性。结果A组sEPCR、vWF、IL-6水平均高于B组,差异有统计学意义(P<0.05)。随着ACI严重程度增加,ACI患者的IL-6、sEPCR和vWF的表达水平逐步升高,差异有统计学意义(P<0.05)。sEPCR和vWF与IL-6和病情严重程度呈正相关(P<0.05)。结论IL-6和病情严重程度与sEPCR和vWF呈正相关,合理应用sEPCR和vWF检测能提升对急性脑梗死病情严重程度评估的效能。Objective To investigate the clinical value of soluble endothelial protein C receptor(sEPCR) and von Willebrand factor(vWF) in the severity assessment of patients with acute cerebral infarction(ACI) and their relationship with interleukin-6(IL-6).Methods We selected 125 patients with ACI(group A) who were admitted to the Department of Neurology of Yan’ an University Affiliated Hospital from January 2017 to January 2019,and 103 people(group B) who had physical examination in the same hospital during the same period.Group A was divided by the severity of ACI into mild group(63 cases),moderate group(39 cases),and severe group(23 cases).We analyzed the clinical value of serum sEPCR and vWF in the diagnosis and prognosis assessment of ACI and their correlation with IL-6.Results The levels of sEPCR,vWF,and IL-6 in group A were significantly higher than those in group B(P<0.05).With the increase in ACI severity,the levels of sEPCR,vWF,and IL-6 significantly increased(P<0.05).The levels of sEPCR and vWF had positive correlations with the level of IL-6 and the severity of the disease(P<0.05).Conclusions sEPCR and vWF are positively correlated with IL-6 and disease severity in ACI. sEPCR and vWF detection may effectively improve the assessment of the severity of ACI.

关 键 词：急性脑梗死 可溶性血管内皮细胞蛋白C受体 血管性血友病因子 白介素-6 

分 类 号：R743.33[医药卫生—神经病学与精神病学]