MRI参数联合血清MIF、miR-1203在肝细胞肝癌早期诊断中的价值及与疗效的关系  

The value of MRI parameters combined with serum MIF and miR-1203 in the early diagnosis of hepatocellular carcinoma and its relationship with efficacy

作　　者：游长金 邓娟[1] 崔俐莉 You Changjin;Deng Juan;Cui Lili(Department of Radiology,the First Affiliated Hospital of Hunan College of Traditional Chinese Medicine,Zhuzhou 412000,China)

机构地区：[1]湖南中医药高等专科学校附属第一医院放射科,株洲412000

出　　处：《中国医师杂志》2021年第5期734-738,743,共6页Journal of Chinese Physician

摘　　要：目的探讨磁共振成像(MRI)参数联合血清巨噬细胞移动抑制因子(MIF)、微小RNA-1203(miR-1203)在肝细胞肝癌(HCC)早期诊断中的价值及与疗效的关系。方法选取2017年10月至2019年10月湖南中医药高等专科学校附属第一医院收治的100例HCC患者作为观察组,随机选取同期92例肝良性肿瘤患者及102例健康体检者作为对照组、正常对照组,进行前瞻性研究。比较三组间以及不同临床病理特征、不同疗效HCC患者间MRI参数[肝动脉灌注指数(HPI)、容积转移常数(K^(trans))]、血清MIF、miR-1203水平,并探究MRI参数、血清MIF、miR-1203单一及联合诊断HCC的价值,分析各指标与HCC患者疗效的关系。结果观察组HPI、K^(trans)及血清MIF、miR-1203水平>对照组>正常对照组(P<0.05);观察组不同肿瘤长径、分化程度、Child-Pugh分级、远处转移患者的HPI、K^(trans)及血清MIF、miR-1203水平对比差异有统计学意义(P<0.05);HPI、K^(trans)及血清MIF、miR-1203中,HPI及K^(trans)诊断HCC特异度最大均为94.57%,K^(trans)诊断HCC的灵敏度最大,为75.00%,二者联合诊断HCC的曲线下面积(AUC)为0.879,大于HPI、K^(trans)及血清MIF、miR-1203单一诊断的AUC(0.753、0.793、0.792、0.809),联合诊断的最佳灵敏度及特异度分别为79.00%、86.96%;观察组治疗后有效患者HPI、K^(trans)及血清MIF、miR-1203水平低于无效患者(P<0.05);HCC患者临床疗效与HPI、K^(trans)及血清MIF、miR-1203水平显著相关(P<0.05)。结论HCC患者MRI参数HPI、K^(trans)及血清MIF、miR-1203水平明显升高,在辅助临床诊断HCC方面具有较高应用价值,且与患者临床疗效密切相关,在疗效评估方面也有较大发展潜力。Objective To explore the value of magnetic resonance imaging(MRI)parameters combined with serum macrophage migration inhibitory factor(MIF)and microRNA-1203(miR-1203)in the early diagnosis of hepatocellular carcinoma(HCC)and its relationship with efficacy.Methods From October 2017 to October 2019,100 patients with HCC in Hunan Provincial Hospital of Traditional Chinese Medicine were selected as the observation group.92 patients with benign liver tumor and 102 healthy people were randomly selected as the control group and normal control group.The clinicopathological features,MRI parameters[hepatic artery perfusion index(HPI),volume transfer constant(K^(trans))],serum MIF and miR-1203 levels were compared among the three groups;the value of MRI parameters,serum MIF and miR-1203 in single and combined diagnosis of HCC was explored;the relationship between each index and curative effect of HCC patients was analyzed.Results The levels of HPI,K^(trans),serum MIF and miR-1203 in observation group were higher than those in control group and normal control group(P<0.05);There were significant differences in HPI,K^(trans),serum MIF and miR-1203 levels among patients with different tumor length,differentiation degree,Child Pugh grade and distant metastasis in the observation group(P<0.05).Among HPI,K^(trans) and serum MIF,miR-1203,the specificity of HPI and K^(trans) for diagnosis of HCC were the largest(94.57%),and the sensitivity of K^(trans) for diagnosis of HCC was the largest(75.00%);the area under the curve(AUC)of the combined diagnosis of HCC was 0.879,which was greater than the AUC of the single diagnosis of HPI,K^(trans) and serum MIF,miR-1203(0.753,0.793,0.792,0.809);the optimal sensitivity and specificity of the combined diagnosis were 79.00%and 86.96%,respectively;the levels of HPI,K^(trans),serum MIF,and miR-1203 in effective patients in the observation group were lower than those in the ineffective patients after treatment(P<0.05);the clinical efficacy of HCC patients were significantly correlated with the lev

关 键 词：癌 肝细胞 磁共振成像 巨噬细胞游走抑制因子 miR-1203 

分 类 号：R735.7[医药卫生—肿瘤]