多发性骨髓瘤患者静脉血栓形成机制的研究进展  

Mechanism of venous thrombosis in patients with multiple myeloma

作　　者：邹雅倩 蔡惠丽 周蜜 陈丽 陈海丹[1] 郭静明[1] Zou Yaqian;Cai Huili;Zhou Mi;Chen Li;Chen Haidan;Guo Jingming(Department of Hematology,Yichang Central People′s Hospital,the First Clinical Medical College of Three Gorges University,Yichang 443000,China)

机构地区：[1]湖北省宜昌市中心人民医院血液内科,三峡大学第一临床医学院,443000

出　　处：《中国医师杂志》2021年第5期786-789,共4页Journal of Chinese Physician

基　　金：湖北省自然科学基金青年项目(2017CFB334)。

摘　　要：多发性骨髓瘤是一种浆细胞疾病,发病率在血液系统恶性肿瘤中位居第二位,其并发血栓形成的风险较高,极大地影响了多发性骨髓瘤患者的生活质量甚至危及生命。多发性骨髓瘤患者血栓形成的发病机制较为复杂,目前尚不明确,但有许多机制被认为与多发性骨髓瘤患者高凝状态相关。目前临床上缺乏针对多发性骨髓瘤的血栓形成风险评估模型。故本文针对多发性骨髓瘤患者的静脉血栓形成相关研究及最新进展进行综述,为血栓形成的预防及治疗提供理论依据。Multiple myeloma is a plasma cell disease with the second highest incidence among hematological malignancies.Its risk of concurrent thrombosis is high,which greatly affects the quality of life and even endangers life of multiple myeloma patients.The pathogenesis of thrombosis in patients with multiple myeloma is complex,which is still unclear.However many mechanisms are considered to be related to hypercoagulable state in patients with multiple myeloma.Currently,there is a lack of thrombosis risk assessment model for multiple myeloma.Therefore,this paper reviews the research and the latest progress of venous thrombosis in patients with multiple myeloma,and provides a theoretical basis for the prevention and treatment of thrombosis.

关 键 词：多发性骨髓瘤 静脉血栓形成 血液凝固障碍 

分 类 号：R733.3[医药卫生—肿瘤]