Nanoplatforms for Sepsis Management: Rapid Detection/Warning, Pathogen Elimination and Restoring Immune Homeostasis  

作　　者：Gan Luo Jue Zhang Yaqi Sun Ya Wang Hanbin Wang Baoli Cheng Qiang Shu Xiangming Fang 

机构地区：[1]Department of Anesthesiology and Intensive Care,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,People’s Republic of China [2]National Clinical Research Center for Child Health,Children’s Hospital,School of Medicine,Zhejiang University,Hangzhou 310052,People’s Republic of China

出　　处：《Nano-Micro Letters》2021年第6期31-94,共64页纳微快报（英文版）

基　　金：the National Key Research and Development Program of China(Grant No.2018YFC2001904).

摘　　要：Sepsis,a highly life-threatening organ dysfunction caused by uncontrollable immune responses to infection,is a leading contributor to mortality in intensive care units.Sepsis-related deaths have been reported to account for 19.7%of all global deaths.However,no effective and specific therapeutic for clinical sepsis management is available due to the complex pathogenesis.Concurrently eliminating infections and restoring immune homeostasis are regarded as the core strategies to manage sepsis.Sophisticated nanoplatforms guided by supramolecular and medicinal chemistry,targeting infection and/or imbalanced immune responses,have emerged as potent tools to combat sepsis by supporting more accurate diagnosis and precision treatment.Nanoplatforms can overcome the barriers faced by clinical strategies,including delayed diagnosis,drug resistance and incapacity to manage immune disorders.Here,we present a comprehensive review highlighting the pathogenetic characteristics of sepsis and future therapeutic concepts,summarizing the progress of these well-designed nanoplatforms in sepsis management and discussing the ongoing challenges and perspectives regarding future potential therapies.Based on these state-of-the-art studies,this review will advance multidisciplinary collaboration and drive clinical translation to remedy sepsis.

关 键 词：SEPSIS Nanoplatform DETECTION Immune homeostasis 

分 类 号：R459.7[医药卫生—急诊医学] TB383.1[医药卫生—治疗学]