Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics  

作　　者：Jiang Ouyang Ling Zhang Leijiao Li Wei Chen Zhongmin Tang Xiaoyuan Ji Chan Feng Na Tao Na Kong Tianfeng Chen You-Nian Liu Wei Tao 

机构地区：[1]The First Affiliated Hospital,Department of Chemistry,Jinan University,Guangzhou 510632,Guangdong,People’s Republic of China [2]Center for Nanomedicine and Department of Anesthesiology,Brigham and Women’s Hospital,Harvard Medical School,Boston,MA 02115,USA [3]College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,Hunan,People’s Republic of China [4]School of Chemistry and Environmental Engineering,Changchun University of Science and Technology,Changchun 130022,Jilin Province,People’s Republic of China

出　　处：《Nano-Micro Letters》2021年第6期108-125,共18页纳微快报（英文版）

基　　金：the US METAvivor Early Career Investigator Award(W.T.)and Harvard Medical School/Brigham and Women’s Hospital Department of Anesthesiology-Basic Scientist Grant(W.T.);National Natural Science Foundation of China(Nos.21877049,21807117);Major Program for Tackling Key Problems of Industrial Technology in Guangzhou(201902020013);Dedicated Fund for Promoting High-Quality Marine Economic Development in Guangdong Province(GDOE-2019-A31,2020-035);Dr J.Ouyang was supported by the China Postdoctoral Science Foundation(No.2020M683173).

摘　　要：Stanene(Sn)-based materials have been extensively applied in industrial production and daily life,but their potential biomedical application remains largely unexplored,which is due to the absence of the appropriate and effective methods for fabricating Sn-based biomaterials.Herein,we explored a new approach combining cryogenic exfoliation and liquid-phase exfoliation to successfully manufacture two-dimensional(2D)Sn nanosheets(SnNSs).The obtained SnNSs exhibited a typical sheet-like structure with an average size of~100 nm and a thickness of~5.1 nm.After PEGylation,the resulting PEGylated SnNSs(SnNSs@PEG)exhibited good stability,superior biocompatibility,and excellent photothermal performance,which could serve as robust photothermal agents for multi-modal imaging(fluorescence/photoacoustic/photothermal imaging)-guided photothermal elimination of cancer.Furthermore,we also used first-principles density functional theory calculations to investigate the photothermal mechanism of SnNSs,revealing that the free electrons in upper and lower layers of SnNSs contribute to the conversion of the photo to thermal.This work not only introduces a new approach to fabricate 2D SnNSs but also establishes the SnNSs-based nanomedicines for photonic cancer theranostics.This new type of SnNSs with great potential in the field of nanomedicines may spur a wave of developing Sn-based biological materials to benefit biomedical applications.

关 键 词：Stanene Two-dimensional Cryogenic exfoliation Cancer theranostics NANOMEDICINE 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤] TQ134.32[医药卫生—临床医学]