有氧运动联合抗阻训练对男性阿片类依赖者血浆催产素、血管加压素和焦虑状态的影响  

Effects of aerobic exercise combined resistance training on plasma oxytocin,arginine vasopressin and anxiety in male opioids-dependent addicts

作　　者：郭吟[1,2] 刘晶琳 黄婷 谭君 张军[4] 郑澜 Guo Yin;Liu Jinglin;Huang Ting;Tan Jun;Zhang Jun;Zheng Lan(Physical Education College,Hunan Normal University,Changsha 410012,China;Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province,Hunan Normal University,Changsha 410012,China;Hunan International Economic University,Changsha 410205,China;Hunan Judicial Police Vocational College,Changsha 410131,China)

机构地区：[1]湖南师范大学体育学院,长沙410012 [2]湖南师范大学体适能与运动康复湖南省重点实验室,长沙410012 [3]湖南涉外经济学院,长沙410205 [4]湖南司法警官职业学院,长沙410131

出　　处：《中华行为医学与脑科学杂志》2021年第5期440-445,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家重点研发计划(2016YFC0800908);中国博士后基金项目(2017M622580);湖南省哲学社会科学基金(18YBQ088)。

摘　　要：目的:观察男性阿片类依赖者运动干预后血浆催产素(oxytocin,OT)、血管加压素(arginine vasopressin,AVP)及焦虑水平的变化。方法:选取符合入组标准并自愿参加运动戒毒的男性阿片类戒毒人员45名,按照分层随机抽样,将其分为运动组(n=22)和对照组(n=23),运动组进行8周、每周5次的有氧联合抗阻训练干预。其中,有氧运动以跑步机和椭圆仪为主,抗阻训练则以力量耐力训练为主。干预前后受试者填写焦虑自评量表(self-rating anxiety scale,SAS)和中文版压力知觉量表(Chinese perceived stress scale,CPSS),进行体适能测试,并检测血浆OT和AVP水平。采用SPSS 20.0进行独立样本t检验,配对t检验和χ^(2)检验。结果:干预前,两组受试者人口学、吸毒史、SAS、CPSS、血浆OT和AVP比较均无统计学意义(P>0.05)。总体焦虑检出率为66.67%,SAS、CPSS均高于中国常模,差异有统计学意义(均P<0.01);干预后,运动组血浆AVP水平、SAS和CPSS得分[AVP(19.57±2.23)pg/ml,SAS(50.17±10.09)分,CPSS(36.59±6.36)分]显著低于对照组[AVP(22.53±2.56)pg/ml,SAS(57.12±12.00)分,CPSS(43.09±5.57)分,均P<0.05],且血浆OT[(61.98±5.27)pg/ml]显著高于对照组[(54.64±7.62)pg/ml](P<0.01);与干预前相比,运动组最大摄氧量(VO 2max)、1 min俯卧撑和坐位体前屈明显提升,差异具有统计学意义(P<0.05)。结论:阿片类药物依赖者在戒毒过程中容易出现过大压力和焦虑等负性情绪;8周有氧运动联合抗阻训练能够对于男性阿片类戒毒人员的血浆OT和AVP水平、知觉压力、焦虑状态和健康体适能水平有一定改善作用。Objective To observe the changes of plasma oxytocin(OT),arginine vasopressin(AVP)and anxiety after exercise intervention in male opioids-dependent patients.Methods Forty-five male opioids addicts who met the inclusion criteria and voluntarily participated in exercise rehabilitation were enrolled.According to stratified random sampling,all subjects were divided into exercise group(n=22)and control group(n=23).Exercise group attended aerobic exercise combined with resistance training intervention,5 times per week for 8 weeks.Aerobic exercise was mainly treadmill and elliptical,while resistance training was based on strength and endurance training.Subjects completed self-rating anxiety scale(SAS)and Chinese perceived stress perception scale(CPSS)before and after intervention,as well as physical fitness tests.Besides,plasma OT and AVP levels were detected.Independent sample t-test,paired sample t-test,and Chi-square test were conducted by using SPSS 20.0 software.Results Before the intervention,there were no significant differences between the two groups in demography,drug history,SAS,CPSS,plasma OT and AVP(all P>0.05).The overall anxiety detection rate was 66.67%,the scores of SAS and CPSS were both higher than the Chinese norm,and the difference was significant(both P<0.01).After the intervention,the levels of plasma AVP,the scores of SAS and CPSS in the exercise group(AVP(19.57±2.23)pg/ml,SAS(50.17±10.09),CPSS(36.59±6.36))were significantly lower than those in the control group(AVP(22.53±2.56)pg/ml,SAS(57.12±12.00),CPSS(43.09±5.57),all P<0.05),and plasma OT((61.98±5.27)pg/ml)was significantly higher than that in the control group((54.64±7.62)pg/ml)(P<0.01).Compared with baseline,maximal oxygen uptake(VO2max),1 min push-ups and sitting body flexion increased significantly in the exercise group(all P<0.05).Conclusion Opioids drug addicts were prone to excessive stress and anxiety and other negative emotions in the process of drug withdrawal.Eight-week aerobic combined with resistance exercise changed the pla

关 键 词：阿片类依赖 运动 催产素 血管加压素 焦虑 

分 类 号：R749.61[医药卫生—神经病学与精神病学] R493[医药卫生—临床医学]