动脉粥样硬化性脑梗死患者载脂蛋白E与三酰甘油、LDL-C的水平变化及意义  

Changes and Significance of Apolipoprotein E,Triglyceride and LDL-C Levels in Patients with Atherosclerotic Cerebral Infarction

作　　者：陈雪枝[1] CHEN Xuezhi(The Second Department of Internal Medicine,Chaozhou Central Hospital,Chaozhou,Guangdong Province,521000 China)

机构地区：[1]潮州市中心医院内二科,广东潮州521000

出　　处：《中外医疗》2021年第12期22-24,共3页China & Foreign Medical Treatment

摘　　要：目的探讨动脉粥样硬化性脑梗死患者载脂蛋白E(ApoE)与三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)的水平变化及意义。方法方便选取该院2019年1月—2020年1月收治的动脉粥样硬化性脑梗死217例,设为研究组,同期纳入接受体检的健康人群158名,设为对照组,分别检测两组受检者的ApoE与TG、LDL-C的水平,探究其临床意义。结果对照组的TG(1.28±0.58)mmol/L、LDL-C(2.16±0.95)mmol/L、ApoE(21.58±2.95)g/L水平低于研究组(2.92±1.85)mmol/L、(3.59±0.31)mmol/L、(48.56±1.85)g/L,差异有统计学意义(t=10.761、20.719、108.518,P<0.05)。Spearman相关分析显示,血清TG、LDL-C与ApoE存在显著相关性(r_(s)=0.419、0.354,P<0.05)。结论ApoE参与了动脉粥样硬化性脑梗死患者血脂代谢,血脂代谢异常与动脉粥样硬化有一定的相关性,通过对TG、LDL-C、ApoE水平变化进行探究,能够为脑血管疾病患者一级、二级预防提供理论依据。Objective To investigate the changes and significance of apolipoprotein E(ApoE),triglycerides(TG)and low-density lipoprotein cholesterol(LDL-C)in patients with atherosclerotic cerebral infarction.Methods Conveniently select 217 cases of atherosclerotic cerebral infarction admitted to the hospital from January 2019 to January 2020 were enrolled and set as the study group.At the same time,158 healthy people who received physical examination were enrolled and set as the control group.The two groups of subjects were tested separately of the levels of ApoE,TG,and LDL-C,to explore its clinical significance.Results The levels of TG(1.28±0.58)mmol/L,LDL-C(2.16±0.95)mmol/L,and ApoE(21.58±2.95)g/L in the control group were lower than those in the study group(2.92±1.85)mmol/L,(3.59±0.31)mmol/L,(48.56±1.85)g/L,the difference was statistically significant(t=10.761,20.719,108.518,P<0.05).Spearman correlation analysis showed that there was a significant correlation between serum TG,LDL-C and ApoE(r_(s)=0.419,0.354,P<0.05).Conclusion ApoE is involved in blood lipid metabolism in patients with atherosclerotic cerebral infarction.Abnormal blood lipid metabolism has a certain correlation with atherosclerosis.Exploring the changes in the levels of TG,LDL-C,and ApoE can help patients with cerebrovascular disease,provide theoretical basis for primary and secondary prevention.

关 键 词：动脉粥样硬化 脑梗死 载脂蛋白E 三酰甘油 LDL-C 

分 类 号：R743.33[医药卫生—神经病学与精神病学]