胃癌组织中CSN6的表达及临床意义  

Expression of CSN6 in gastric cancer tissue and its clinical significance

作　　者：卓长华[1] 阮强 林瑞榕 张和军[3] 杨春康[1] ZHUO Chang-hua;RUAN Qiang;Lin Rui-rong(Departments of Gastrointestinal Surgical Oncology,Fujian Provincial Cancer Hospital,Cancer Hospital Affiliated to Fujian Medical University,Fuzhou 350014,China;chemical college,Fuzhou University,Fuzhou 350108,China;Department of Pathology,Fujian Procinical Cancer Hospital,Cancer Hospital Affiliated to Fujian Medical University,Fuzhou 350014,China)

机构地区：[1]福建省肿瘤医院,福建医科大学附属肿瘤医院胃肠肿瘤外科,福建福州350014 [2]福州大学化学学院,福建福州350108 [3]福建省肿瘤医院,福建医科大学附属肿瘤医院病理科,福建福州350014

出　　处：《吉林医学》2021年第6期1294-1298,共5页Jilin Medical Journal

基　　金：福建省科技创新联合资金项目[项目编号:2018Y9106];福建省自然科学基金面上项目[项目编号:2019J01198]。

摘　　要：目的:观察组成型光形态发生因子9信号复合体亚基6(Constitutive photomorphogenesis 9 signalosome subunit 6,CSN6)在胃癌组织中的表达,并探讨其临床价值。方法:收集2019年11月~2020年2月手术切除的30例新鲜胃癌及癌旁组织,采用Western blot检测30例新鲜胃癌及癌旁组织中CSN6表达量。选取2013年1月~2015年9月病理科存档的170例胃癌石蜡组织及癌旁组织,采用免疫组化检测CSN6的表达情况。结果:新鲜组织胃癌中CSN6表达量为1.821±0.421,高于癌旁组织的0.976±0.311,差异有统计学意义(P<0.05)。石蜡组织中,CSN6在胃癌组织中的阳性率为55.3%,高于癌旁正常组织的28.8%。CSN6的阳性表达与胃癌的浸润深度、淋巴结转移、病理分期有关。CSN6阳性患者的5年生存率为41.6%,低于阴性患者的60.1%,差异有统计学意义(P<0.05)。单因素分析表明CSN6、肿瘤大小、分化程度、神经浸润、脉管癌栓、浸润深度、淋巴结转移、病理分期与患者预后有关。多因素分析表明,CSN6、分化程度、浸润深度、淋巴结转移、病理分期是胃癌预后的独立危险因素,差异有统计学意义(P<0.05)。结论:CSN6参与胃癌的发生及发展,是判断胃癌预后及靶向治疗的重要分子标志物。Objective To observe the expression of Constitutive photomorphogenesis 9 signalosome subunit 6(CSN6)in gastric cancer tissues and to explore their clinical significance.Method 30 fresh gastric cancer and adjacent tissues resected in our hospital from November 2019 to February 2020 were collected.Western blot was used to detect the expression of CSN6 in 30 cases of fresh gastric cancer and adjacent tissues.170 cases of gastric cancer paraffin tissues and paracancerous tissues archived from January 2013 to September 2015 in our hospital were selected,and the expression of CSN6 was detected by immunohistochemistry.Results The expression of CSN6 in fresh tissue gastric cancer was 1.821±0.421,which was higher than 0.976±0.311 in adjacent tissues(P<0.05).In paraffin tissue,the positive rate of CSN6 in gastric cancer tissue was 55.3%,which was higher than 28.8%in normal tissue adjacent to cancer.The expression of CSN6 was related to the depth of invasion,lymph node metastasis and pathological staging of gastric cancer.The 5-year survival rate of CSN6 positive patients was 41.6%,which was lower than the 60.1%of negative patients(P<0.05).Univariate analysis showed that CSN6,tumor size,degree of differentiation,nerve invasion,vascular tumor thrombus,depth of invasion,lymph node metastasis and pathological stage were related to the prognosis of patients.Multivariate analysis showed that CSN6,degree of differentiation,depth of invasion,lymph node metastasis,and pathological staging were independent risk factors for the prognosis of gastric cancer(P<0.05).Conclusion CSN6 is involved in the occurrence and development of gastric cancer,and is an important molecular marker for judging the prognosis of gastric cancer and targeted therapy.

关 键 词：胃癌 CSN6 预后 

分 类 号：R735.2[医药卫生—肿瘤]