甲磺酸阿帕替尼联合正念减压疗法对晚期卵巢癌患者的癌因性疲乏、自我效能感及肿瘤血管生长因子的影响  

Effects of apatinib mesylate combined with mindfulness based stress reduction therapy on oncogenic fatigue,self-efficacy and tumor vascular growth factor in patients with advanced ovarian cancer

作　　者：刘红[1] 王爱香[1] 桑秀丽[1] 周晓艳[2] LIU Hong;WANG Aixiang;SANG Xiuli(Department of Obstetrics and Gynecology,Third People's Hospital of Anyang,Anyang 455000,China)

机构地区：[1]安阳市第三人民医院妇产科,安阳455000 [2]安阳市第三人民医院神经内科

出　　处：《国际精神病学杂志》2021年第2期316-319,共4页Journal Of International Psychiatry

摘　　要：目的探讨甲磺酸阿帕替尼联合正念减压疗法(MBSR)对晚期卵巢癌患者癌因性疲乏、自我效能感及肿瘤血管生长因子的影响。方法选取我科2018年7月~2020年9月期间收治的115例晚期卵巢癌患者随机分为两组,对照组57例给予多西他赛注射液联合顺铂注射液,观察组58例在对照组治疗的基础上联合甲磺酸阿帕替尼片及MBSR,比较两组患者治疗后的癌因性疲乏、自我效能感、肿瘤血管生长因子及不良反应。结果两组患者在治疗后,癌因性疲乏程度、自我效能感均较治疗前改善,且观察组改善幅度高于对照组(P<0.05);两组患者在治疗后,肿瘤血管生长因子均较治疗前降低,且观察组降低幅度高于对照组(P<0.05)。结论甲磺酸阿帕替尼联合正念减压疗法能够有效抑制晚期卵巢癌患者肿瘤细胞的生长,缓解患者身体和心理的压力,改善患者癌因性疲乏和自我效能感,降低不良反应的发生率。Objective To investigate the effects of apatinib mesylate combined with MBSR on cancer-induced fatigue,self-efficacy and tumor vascular growth factor in patients with advanced ovarian cancer. Method From July 2018 to September 2020,115 cases of advanced ovarian cancer patients was selected and divided randomly two groups,57 cases in the control group were treated Docetaxel combined cisplatin injection,58 cases in the observation group added Apatinib Mesylate and MBSR. The cancer-related fatigue,self-efficacy and tumor vascular growth factors,and adverse reactions between two groups were compared. Results After treatment,the degree of cancer-related fatigue and self-efficacy in both groups were improved,and the degree of improvement in the observation group was more than that in the control group(P< 0.05). After treatment,tumor vascular growth factor was reduced in both groups compared with that before treatment,and the degree of reduction in the observation group was more than that in the control group(P< 0.05). Conclusion Apatinib mesylate combined with mindfulness based stress reduction therapy can effectively inhibit the growth of tumor cells,relieve the physical and psychological pressure of patients,improve patients’ cancer-related fatigue and self-efficacy,and reduce the incidence of adverse reactions in advanced ovarian cancer patients.

关 键 词：甲磺酸阿帕替尼 正念减压 晚期卵巢癌 癌因性疲乏 肿瘤血管生长因子 

分 类 号：R749.2[医药卫生—神经病学与精神病学]