帕罗西汀对结直肠癌脑转移术后患者的精神状况及认知功能的影响  

Effects of paroxetine on mental status and cognitive function of patients with colorectal cancer after brain metastasis

作　　者：王雁军[1] 王青兵[1] 张勇[1] 牛志强[1] WANG Yanjun;WANG Qingbing;ZHANG Yong(Anyang Cancer Hospital,Anyang 455000,China)

机构地区：[1]安阳市肿瘤医院,安阳455001

出　　处：《国际精神病学杂志》2021年第2期320-322,329,共4页Journal Of International Psychiatry

摘　　要：目的探讨帕罗西汀对结直肠癌脑转移术后患者认知功能、精神状况及负面情绪的影响。方法选取我院2017年1月~2020年5月期间88例结直肠癌脑转移术后患者,根据随机数字表法分组。对照组44例给予心理干预和安慰剂,观察组44例在此基础上增加帕罗西汀治疗,3个月后,对比两组患者神经递质因子:5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)水平;精神状况:以汉密尔顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)评估;认知功能:以MMSE量表评估认知功能。结果治疗后观察组5-HT、BDNF水平、MMSE评分高于对照组,HAMA、HAMD评分低于对照组(P<0.05)。结论帕罗西汀可有效改善结直肠癌脑转移术后患者的神经功能,减轻抑郁症状,促进认知功能的恢复。Objective To explore the effect of paroxetine on the cognitive function,mental status and negative emotions of patients with colorectal cancer after brain metastasis. Methods Selected 88 patients with colorectal cancer brain metastasis from January 2017 to May 2020 in our hospital,and grouped them according to the random number table method. Forty-four patients in the control group were given psychological intervention and placebo,and 44 patients in the observation group were treated with paroxetine. After 3 months of treatment,the two groups of patients were compared with the level of 5-hydroxytryptamine(5-HT),the level of brain-derived Neurotrophic factor(BDNF),Hamilton Anxiety Scale(HAMA)scores,Hamilton Depression Scale(HAMD)socres,amd the scores of MMSE. Results After treatment,the 5-HT level,BDNF level and MMSE scores in the observation group were higher than those in the control group,and the HAMA and HAMD scores were lower than those in the control group(P<0.05). Conclusion Paroxetine can effectively improve neurological function,reduce depression symptoms,and promote the recovery of cognitive function in patients with colorectal cancer after brain metastasis.

关 键 词：帕罗西汀 结直肠癌脑转移 精神状况 认知功能 

分 类 号：R749.2[医药卫生—神经病学与精神病学]