lncRNA ANRIL rs2383207及其交互效应与急性缺血性脑卒中早期神经功能恶化的关系  

Relationship between lncRNA ANRIL rs2383207 and its interaction with early neurological deterioration in patients with acute ischemic stroke

作　　者：黄燕 周嫱 陈小灵 唐志[3] 何发毅 冯玉环 柳华 HUANG Yan;ZHOU Qiang;CHEN Xiao-ling;TANG Zhi;HE Fa-yi;FENG Yu-huan;LIU Hua(Department of Neurology,the People's Hospital of Yanting City,Mianyang 621600;Department of Neurology,the Third People's Hospital of Chengdu&the Affiliated Hospital of Southwest Jiaotong University,Chengdu 610031;Department of Neurosurgery,the People's Hospital of Yanting City,Mianyang 621600,Sichuan,China)

机构地区：[1]盐亭县人民医院神经内科,四川绵阳621600 [2]成都市第三人民医院·西南交通大学附属医院神经内科,四川成都610031 [3]盐亭县人民医院神经外科,四川绵阳621600

出　　处：《川北医学院学报》2021年第5期622-626,共5页Journal of North Sichuan Medical College

基　　金：四川省绵阳市卫计委项目(201836)。

摘　　要：目的:探讨INK4基因座中反义非编码RNA(ANRIL)基因与急性缺血性脑卒中(CIS)早期神经功能恶化(END)的相关性。方法:采用候选基因关联研究方法,以ANRIL基因单核苷酸多态性rs2383207位点为遗传标记,分析END发病与ANRIL基因的相关性,同时分析基因-END传统危险因素的交互作用。结果:高血糖、高同型半胱氨酸和神经功能缺损程度(NIHSS>5)与END发病风险独立相关(P<0.05);rs2383207多态位点与END发病显著相关(P<0.05),GG基因型增加了END发病风险[GG基因型:比值比(OR)=2.143,95%置信区间(CI)=1.293-3.550,P=0.003];A等位基因降低了END患病风险(OR=0.691,95%CI:0.497-0.961,P=0.028)。rs2383207位点与神经功能缺损程度(NHSS>5)之间具有交互效应,交互作用增加了END的易感性(OR=1.696)。结论:ANRIL基因可能与汉族人群急性CIS期间END发病风险相关。Objective:To explore the association of Antisense non-coding RNA in the INK4 locus(ANRIL)gene with increased risk of early neurological deterioration(END)in acute cerebral ischemic stroke(CIS).Methods:Using the candidate gene association method,the single nucleotide polymorphism rs2383207 of ANRIL gene was used as a genetic marker to analyze the correlation between END and ANRIL gene,and the interaction between gene and traditional risk factors of END.Results:The hyperglycemia,homocysteine and neurologic deficit(NIHSS>5)were independently related to the risk of END(P<0.05),and rs2383207 polymorphism were significantly associated with END(P<0.05),GG genotype increases the risk of END[GG genotype:odds ratio(OR)=2.143,95%confidence interval(CI)(1.293-3.550),P=0.003],allele A reduces the risk of END[OR=0.691,95%CI:(0.497-0.961),P=0.028].The interaction of rs2383207 and neurologic deficit(NIHSS>5)increased susceptibility to END[OR=1.696].Conclusion:ANRIL gene may be associated with the risk of END during acute CIS in Han population.

关 键 词：缺血性脑卒中 早期神经功能恶化 ANRIL基因 单核苷酸多态性 交互作用 

分 类 号：R743.3[医药卫生—神经病学与精神病学]