首发精神分裂症患者同型半胱氨酸水平和骨代谢标志物相关性研究  

Study on the correlation between homocysteine level and bone metabolism markers in patients with fist-episode schizophrenia

作　　者：吴勇 万静 平军娇 黄彩英 杜启峰 杜宝国 WU Yong;WAN Jing;PING Jun-jiao;HUANG Cai-ying;DU Qi-feng;DU Bao-guo(Department of Medical Administration,Zhongshan Third People′s Hospital,Guangdong Province,Zhongshan 528400,China;Department of Early Intervention,Zhongshan Third People′s Hospital,Guangdong Province,Zhongshan 528400,China;Department of Science and Education(Institute of Mental Health),Zhongshan Third People′s Hospital,Guangdong Province,Zhongshan 528400,China)

机构地区：[1]广东省中山市第三人民医院医务部,广东中山528400 [2]广东省中山市第三人民医院早期干预科,广东中山528400 [3]广东省中山市第三人民医院科教科(精研所),广东中山528400

出　　处：《中国当代医药》2021年第16期82-85,共4页China Modern Medicine

基　　金：广东省中山市医学科研基金项目(2018J159)。

摘　　要：目的探讨首发精神分裂症患者同型半胱氨酸(HCY)水平与骨代谢标志物的相关性。方法以《ICD-10精神与行为障碍分类》精神分裂症诊断标准,选取2016年5月~2020年4月中山市第三人民医院收治的69例首发精神分裂症患者作为研究对象。根据患者HCY水平,将其分为高HCY组(HCY>15.4μmol/L,31例)和正常HCY组(HCY≤15.4μmol/L,38例)。收集两组患者的一般资料、HCY、骨代谢标志物[骨钙素(OCN)、β-型胶原分解产物(β-CTX)、25-羟维生素D(VitD-T)、Ⅰ型胶原羧基端前肽(PⅠNP)和甲状旁腺激素(PTH)]及心脑血管相关指标[三酰甘油(TG)、总胆固醇(TC)、超敏C反应蛋白(hs-CRP)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)],分析其差异性与相关性。结果高HCY组患者的CK、CK-MB及PⅠNP水平均高于正常HCY组,差异有统计学意义(P<0.05);两组患者的hs-CRP、TG、TC、HDL、OCN、β-CTX、VitD-T、PTH和LDL水平比较,差异无统计学意义(P>0.05)。相关性分析发现,患者HCY水平与CK、CK-MB及HDL水平呈正相关性(P<0.05);患者HCY水平与PⅠNP呈正相关性(P<0.05)。结论HCY水平与首发精神分裂症患者骨代谢标志物有一定相关性,与心脑血管相关指标也存在一定关联。Objective To investigate the correlation between homocysteine(HCY)level and bone metabolic markers in patients with first-episode schizophrenia.Methods A total of 69 patients with first-episode schizophrenia who were admitted to Zhongshan Third People′s Hospital from May 2016 to April 2020 were selected as the research objects according to the International Classification of Diseases 10th edition Mental and Behavioral Disorders.Patients were divided into high HCY group(HCY>15.4μmol/L,with 31 cases)and normal HCY group(HCY≤15.4μmol/L,with 38 cases)according to the HCY level of patients.General data,HCY,bone metabolism markers(osteocalcin[OCN],β-collagen breakdown product[β-CTX],25-hydroxy vitamin D[VitD-T],procollagen typeⅠN propeptide[PⅠNP]and parathyroid hormone[PTH])and cerebrovascular-related indexes(triacylglycerol[TG],total cholesterol[TC],high-sensitivity C-reactive protein[hs-CRP],high-density lipoprotein[HDL],low density lipoprotein[LDL],creatine kinase[CK],creatine kinase isoenzyme[CK-MB])in the two groups were collected,and their differences and correlation were analyzed.Results The levels of CK,CK-MB and PⅠNP in the high HCY group were higher than those in the normal HCY group,and the differences were statistically significant(P<0.05).There were no significant differences in the levels of hs-CRP,TG,TC,HDL,OCN,β-CTX,VitD-T,PTH and LDL between the two groups(P>0.05).Correlation analysis showed that HCY level was positively correlated with CK,CK-MB and HDL levels in schizophrenia patients(P<0.05).HCY was positively correlated with PⅠNP(P<0.05).Conclusion HCY level has a certain correlation with bone metabolism markers in patients with first-episode schizophrenia,and also has a certain correlation with cerebrovascular-related indexes.

关 键 词：精神分裂症 同型半胱氨酸 骨代谢标志物 差异性 相关性 

分 类 号：R749[医药卫生—神经病学与精神病学]