Stem cell therapy in ocular pathologies in the past 20 years  

作　　者：Giovanni Miotti Pier Camillo Parodi Marco Zeppieri 

机构地区：[1]Department of Plastic Surgery,University Hospital of Udine,Udine 33100,Italy [2]Department of Ophthalmology,University Hospital of Udine,Udine 33100,Italy

出　　处：《World Journal of Stem Cells》2021年第5期366-385,共20页世界干细胞杂志（英文版）（电子版）

摘　　要：Stem cell therapies are successfully used in various fields of medicine.This new approach of research is also expanding in ophthalmology.Huge investments,resources and important clinical trials have been performed in stem cell research and in potential therapies.In recent years,great strides have been made in genetic research,which permitted and enhanced the differentiation of stem cells.Moreover,the possibility of exploiting stem cells from other districts(such as adipose,dental pulp,bone marrow stem cells,etc.)for the treatment of ophthalmic diseases,renders this topic fascinating.Furthermore,great strides have been made in biomedical engineering,which have proposed new materials and threedimensional structures useful for cell therapy of the eye.The encouraging results obtained on clinical trials conducted on animals have given a significant boost in the creation of study protocols also in humans.Results are limited to date,but clinical trials continue to evolve.Our attention is centered on the literature reported over the past 20 years,considering animal(the most represented in literature)and human clinical trials,which are limiting.The aim of our review is to present a brief overview of the main types of treatments based on stem cells in the field of ophthalmic pathologies.

关 键 词：Stem cells Multipotent mesenchymal cells Adipose stem cells Novel therapies Eye pathology CORNEA Cell therapies New materials 

分 类 号：R457.7[医药卫生—治疗学] R77[医药卫生—临床医学]