培美曲塞联合卡铂治疗晚期肺腺癌的临床观察  

Clinical observation of pemetrexed combined with carboplatin in the treatment of advanced lung adenocarcinoma

作　　者：陈康彪[1] 劳逸[1] 黄潞[1] 谢馨[1] 叶妍妍 李明[1] 吴业 黄康淼 Chen Kangbiao;Lao Yi;Huang Lu;Xie Xin;Ye Yanyan;Li Ming;Wu Ye;Huang Kangmiao(The Fourth Area of Internal Oncology,Guangdong Agricultural Reclamation Center Hospital,Guangdong Zhanjiang 524001)

机构地区：[1]广东省农垦中心医院肿瘤内科四区,广东湛江524001

出　　处：《中国社区医师》2021年第16期18-19,共2页Chinese Community Doctors

摘　　要：目的:探究培美曲塞联合卡铂治疗晚期肺腺癌的临床效果及安全性。方法:2017年1月-2019年5月收治晚期肺癌患者58例,根据治疗方式不同分为两组,各29例。对照组采用多西他赛联合卡铂治疗;观察组采用培美曲塞联合卡铂治疗。比较两组治疗效果。结果:观察组客观缓解率、疾病控制率明显高于对照组,无进展生存时间(PFS)长于对照组,差异有统计学意义(P<0.05);观察组生活质量改善例数高于对照组,不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:培美曲塞联合卡铂治疗晚期肺腺癌的临床疗效确切,特别是在提高生活质量、延长PFS及降低不良反应发生率方面,效果更好。Objective:To explore the clinical efficacy and safety of pemetrexed combined with carboplatin in the treatment of advanced lung adenocarcinoma.Methods:From January 2017 to May 2019,58 patients with advanced lung cancer were selected,they were divided into the two groups with 29 cases in each group.The control group was treated with docetaxel combined with carboplatin.The observation group was treated with pemetrexed combined with carboplatin.The therapeutic effects of the two groups were compared.Results:The objective remission rate and disease control rate in the observation group were significantly higher than those in the control group,and the progression-free survival time(PFS)in the observation group was significantly longer than that in the control group,the difference was statistically significant(P<0.05).The proportion of patients with improved quality of life in the observation group was higher than that in the control group,and the incidence of adverse reactions in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Pemetrexed combined with carboplatin is effective in the treatment of advanced lung adenocarcinoma,especially in improving quality of life,prolonging progression-free survival time and reducing the incidence of adverse reactions.

关 键 词：培美曲塞 多西他赛 卡铂 晚期肺腺癌 生活质量 不良反应 

分 类 号：R734.2[医药卫生—肿瘤]