Changes in the nutritional status of nine vitamins in patients with esophageal cancer during chemotherapy  

作　　者：Lan-Qing Liang Ling-Ling Meng Bo-Ning Cai Ze-Ping Cui Na Ma Le-Hui Du Wei Yu Bao-Lin Qu Sheng-Qiang Feng Fang Liu 

机构地区：[1]Department of Radiotherapy,Chinese PLA General Hospital,Beijing 100853,China [2]Department of Health Service,The Guard Bureau of Joint Staff Department of Chinese PLA,Beijing 100017,China

出　　处：《World Journal of Gastroenterology》2021年第19期2366-2375,共10页世界胃肠病学杂志（英文版）

基　　金：Health Bureau of the Department of Logistics and Security of the Central Military Commission of China,No.17BJZ47.

摘　　要：BACKGROUND Many studies have investigated the relationships between vitamins and esophageal cancer(EC).Most of these studies focused on the roles of vitamins in the prevention and treatment of EC,and few studies have examined the changes in vitamin nutritional status and their influencing factors before and after chemotherapy for EC.Chemotherapy may have a considerable effect on EC patients’vitamin levels and hematological indicators.AIM To research the nutritional status of multiple vitamins in EC patients during chemotherapy and to assess its clinical significance.METHODS EC patients admitted to our center from July 2017 to September 2020 were enrolled in this study.Serum concentrations of nine vitamins(A,D,E,B9,B12,B1,C,B2 and B6),hemoglobin,total protein,albumin,blood calcium,blood phosphorus concentrations and body mass index(BMI)were measured in all EC patients.The changes in nine vitamins,hematological indicators and BMI were compared before and after two cycles of chemotherapy.The possible influential factors were analyzed.RESULTS In total,203 EC patients receiving chemotherapy were enrolled in this study.Varying degrees of vitamin A,D,C and B2 deficiency and weight loss were found in these patients,and the proportions of vitamin B2 and vitamin C deficiencies increased significantly after chemotherapy(both P<0.05).Serum concentrations of vitamins A,C,B2 and B6 and BMI before and after chemotherapy were statistically significant(all P<0.05).Multivariate analysis showed that vitamin A levels significantly differed between male and female EC patients,whereas vitamin D concentration significantly differed in EC patients in different stages(all P<0.05).Correlations were observed between the changes in serum concentrations of vitamin A and C before and after two cycles chemotherapy and the change in BMI(P<0.05).Hemoglobin,total protein,serum albumin and blood calcium concentrations significantly decreased in EC patients after chemotherapy(all P<0.05),while the blood phosphorus level significantly increased af

关 键 词：Esophageal cancer CHEMOTHERAPY VITAMINS Nutritional status Body mass index 

分 类 号：R735.1[医药卫生—肿瘤]