Effect of antifoaming agent on benign colorectal tumors in colonoscopy:A meta-analysis  

作　　者：Hu Zhang Jing Gong Lin-Song Ma Ting Jiang Heng Zhang 

机构地区：[1]Department of Gastroenterology,The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430014,Hubei Province,China [2]Department of Gastroenterology,The Eighth Hospital of Wuhan,Wuhan 430014,Hubei Province,China

出　　处：《World Journal of Clinical Cases》2021年第15期3607-3622,共16页世界临床病例杂志

基　　金：the Natural Science Foundation of Wuhan,No.WX18Y04.

摘　　要：BACKGROUND Although several trials have shown that the addition of antifoaming agents to polyethylene glycol(PEG)can improve bowel preparation,whether PEG plus antifoaming agents have a beneficial role in the detection of benign tumors during colonoscopy has yet to be confirmed.Our aim was to clarify whether adding simethicone to PEG solution could improve the detection of benign colorectal tumors.AIM To clarify whether adding simethicone to PEG solution could improve the detection of benign colorectal tumors.METHODS The PubMed,EMBASE,and Cochrane Library databases were searched for articles published prior to September 2019.The outcomes included the detection rates of colorectal adenomas and polyps.RESULT Twenty studies were eligible.Although there was no difference in the colorectal adenoma detection rate(ADR),a significant effect of simethicone for diminutive adenomas(<10 mm)was revealed in the group taking simethicone.We also found that simethicone could significantly improve the ADR in the proximal colon but did not affect the colorectal polyp detection rate.Furthermore,the subgroup analyses revealed a beneficial effect of simethicone on the ADR among Asians(P=0.005)and those with an ADR<25%(P=0.003).Moreover,it was a significant finding that the low dose simethicone was as effective as the high dose one with respect to the detection of benign colorectal tumors.CONCLUSION In summary,the addition of simethicone to PEG might improve the detection of diminutive adenomas in the right colon by colonoscopy in Asia.Low-dose simethicone was recommended for the detection of benign colorectal tumors.However,large clinical trials are necessary to validate our results and determine the ideal dose of simethicone.

关 键 词：Antifoaming agent SIMETHICONE Polyethylene glycol COLONOSCOPY Metaanalysis 

分 类 号：R735.34[医药卫生—肿瘤]