Small bowel ulcer bleeding due to suspected clopidogrel use in a patient with clopidogrel resistance:A case report  

作　　者：Sang Hoon Lee Dong Ryeol Ryu Sung Joon Lee Sung Chul Park Byung Ryul Cho Seung Koo Lee Sang Ji Choi Hyun Seok Cho 

机构地区：[1]Division of Gastroenterology,Department of Internal Medicine,Kangwon National University Hospital,Kangwon National University School of Medicine,Chuncheon-si 24289,South Korea [2]Division of Cardiology,Department of Internal Medicine,Kangwon National University Hospital,Kangwon National University School of Medicine,Chuncheon-si 24289,South Korea [3]Department of Anatomic Pathology,Kangwon National University Hospital,Kangwon National University School of Medicine,Chuncheon-si 24289,South Korea [4]Department of Surgery,Kangwon National University Hospital,Kangwon National University School of Medicine,Chuncheon-si 24289,South Korea [5]Department of Hospital Medicine,Kangwon National University Hospital,Chuncheon-si 24289,South Korea

出　　处：《World Journal of Clinical Cases》2021年第15期3689-3695,共7页世界临床病例杂志

摘　　要：BACKGROUND Clopidogrel is a platelet aggregation inhibitor used for the management of cardiovascular disease.While antiplatelet therapy decreases cardiovascular events after successful coronary drug-eluting stenting,it increases the risk of gastrointestinal(GI)bleeding.About 20%of the patients who take clopidogrel exhibit resistance to the drug.CASE SUMMARY We report the first case of a small bowel bleeding ulcer in an 86-year-old man with clopidogrel resistance.He had a history of taking clopidogrel due to unstable angina.There was no evidence of bleeding in the stomach,duodenum,or colon through upper and lower GI endoscopies.The abdominal computed tomography showed the extravasation of radiocontrast media at the ileum.Because of unstable vital signs,emergency surgery was performed.Multiple ulcers with inflammation were found in the ileum.The pathologic findings revealed simple inflammation.The VerifyNow P2Y12 test showed clopidogrel resistance.One year after changing to aspirin,capsule endoscopy was performed and the small bowel ulcers were improved.CONCLUSION Small bowel ulcers and bleeding due to clopidogrel are not very common,but the prevalence is expected to increase in older age patients with risk factors despite clopidogrel resistance.

关 键 词：CLOPIDOGREL Resistance Small bowel Multiple ulcers HEMATOCHEZIA Surgery Case report 

分 类 号：R656.7[医药卫生—外科学]