Lymphangiomatosis associated with protein losing enteropathy:A case report  

作　　者：Xue-Li Ding Xiao-Yan Yin Ya-Nan Yu Yun-Qing Chen Wei-Wei Fu Hua Liu 

机构地区：[1]Department of Gastroenterology,The Affiliated Hospital of Qingdao University,Qingdao 266003,Shandong Province,China [2]Department of Pathology,The Affiliated Hospital of Qingdao University,Qingdao 266003,Shandong Province,China

出　　处：《World Journal of Clinical Cases》2021年第15期3758-3764,共7页世界临床病例杂志

基　　金：The National Natural Science Foundation of China,No.81502025;China Postdoctoral Science Foundation,No.2018M632631.

摘　　要：BACKGROUND Lymphangiomatosis is a multisystem disorder that is rarely localized to the gastrointestinal tract.Lymphangiomatosis usually has no specific clinical presentation and is easily misdiagnosed.A case report and review of the literature on lymphangiomatosis associated with protein-losing enteropathy will help to improve the overall understanding of this disease.CASE SUMMARY We report a case of lymphangiomatosis of the bowel and other solid organs.A 78-year-old man presented with recurrent bowel bleeding and protein-losing enteropathy,as well as cystic lesions in the spleen,liver,and kidney.Imaging examinations revealed many cystic lesions on the spleen,liver,kidney,and thickened wall of the ascending colon,as well as pleural effusion and ascites.Colonoscopy revealed a strawberry mucosa,variable spontaneous bleeding,and surface erosion located in the terminal ileum.Several cystic masses with a translucent and smooth surface as well as diffuse white spots were located in the colon.A laterally spreading tumor(LST)was located in the ascending colon.Pathology indicated highly differentiated adenocarcinoma(LST)and lymphangiomatoid dilation,and D2-40 was positive.The final diagnosis was lymphangiomatosis.The patient underwent surgery for LST and then was administered thalidomide 75-150 mg/d.His condition,however,did not improve.He eventually died 6 mo after the initial diagnosis.CONCLUSION Lymphangiomatosis usually occurs diffusely and can involve many organs,such as the spleen,kidney,liver,lung,mesentery,and bowel.Recurrent bowel bleeding or protein-losing enteropathy is an important indicator that should alert clinicians about the possibility of this disease when it afflicts the bowel.Doctors should improve the medical understanding of lymphangiomatosis.

关 键 词：LYMPHANGIOMA Gastrointestinal hemorrhage Protein-losing enteropathies Colonic neoplasms Small intestine Case report 

分 类 号：R574[医药卫生—消化系统] R733.1[医药卫生—内科学]