Patients with functional bowel disorder have disaccharidase deficiency:A single-center study from Russia  

作　　者：Saria Dbar Olga Akhmadullina Elena Sabelnikova Nikolai Belostotskiy Asfold Parfenov Svetlana Bykova Sergey Bakharev Elena Baulo Alexandra Babanova Lilia Indeykina Tatyana Kuzmina Tatiana Kosacheva Aleksey Spasenov Alina Makarova 

机构地区：[1]Non-inflammatory Bowel Diseases,Moscow Health Department,Moscow Clinical Scientific Center n.a.A.S.Loginov,Moscow 111123,Russia [2]Moscow Health Department,Moscow Clinical Scientific Center n.a.A.S.Loginov,Moscow 111123,Russia [3]Pre-Clinical Research Laboratory,Moscow Clinical Scientific Center Named after A.S.Loginov MHD,Moscow 111123,Russia [4]Department of Bowel Pathology,Moscow Health Department,Moscow Clinical Scientific Center n.a.A.S.Loginov,Moscow 111123,Russia [5]Laboratory of Functional Diagnostics of Intestinal Diseases,Moscow Health Department,Moscow Clinical Scientific Center n.a.A.S.Loginov,Moscow 111123,Russia [6]Nutraceuticals Laboratory,Moscow Health Department,Moscow Clinical Scientific Center n.a.A.S.Loginov,Moscow 111123,Russia [7]Department of Medical Statistics,Moscow Health Department,Moscow Clinical Scientific Center n.a.A.S.Loginov,Moscow 111123,Russia

出　　处：《World Journal of Clinical Cases》2021年第17期4178-4187,共10页世界临床病例杂志

摘　　要：BACKGROUND Functional bowel disorder(FBD)may be caused by a decrease in disaccharidase activity.Thus,the timely diagnosis of disaccharidase deficiency could lead to a better prognosis in patients with this condition.AIM To determine the potential value of intestinal disaccharidases glucoamylase,maltase,sucrase,and lactase in understanding the etiology and pathogenesis of FBD.METHODS A total of 82 FBD patients were examined.According to the Rome IV criteria(2016),23 patients had diarrhea-predominant irritable bowel syndrome(IBS),33 had functional diarrhea,10 had constipation-predominant IBS,4 had functional constipation,and 12 had mixed IBS.The Dahlqvist method was used to measure disaccharidase activity in the brush-border membrane of mature enterocytes of the small intestine,in duodenal biopsies obtained during esophagogastroduodenoscopy.RESULTS Lactase deficiency was detected in 86.5%of patients,maltase deficiency in 48.7%,sucrase deficiency in 50%,and glucoamylase deficiency in 84.1%.The activities of all enzymes were reduced in 31.7%of patients,and carbohydrase deficiency was detected in 63.5%of patients.The low activity of enzymes involved in membrane digestion in the small intestine was found in 95.2%of patients.CONCLUSION In 78 of the 82 patients with FBD,gastrointestinal symptoms were associated with disaccharidase deficiency.

关 键 词：Functional bowel disorder Irritable bowel syndrome Disaccharidase deficiency Maltase deficiency Sucrase deficiency Lactase deficiency 

分 类 号：R574[医药卫生—消化系统]