健神利水颗粒联合呋塞米治疗脑出血继发性脑水肿的临床研究  

Clinical study of Jianshi Lishui Granules combined with Furosemide in the treatment of secondary cerebral edema after cerebral hemorrhage

作　　者：谭璐璐[1] 黄荣森 周观 陈兴华[1] 刘永辉[1] TAN Lulu;HUANG Rongsen;ZHOU Guan;CHEN Xinghua;LIU Yonghui(Department of Encephalopathy,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning 530023,China;Graduate School,Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning 530023,China)

机构地区：[1]广西中医药大学第一附属医院脑病科,广西南宁530023 [2]广西中医药大学研究生学院,广西南宁530023

出　　处：《中国医药导报》2021年第14期72-75,80,共5页China Medical Herald

基　　金：广西中医药适宜技术开发与推广项目(GZSY20-29);广西壮族自治区卫生厅自筹经费科研项目(Z2014100)。

摘　　要：目的探讨健神利水颗粒联合呋塞米治疗脑出血继发性脑水肿的临床效果。方法选取2017年4月—2020年4月广西中医药大学第一附属医院收治的脑出血继发性脑水肿患者100例,根据随机数字表法将其分为对照组和研究组,每组各50例。对照组给予呋塞米治疗,研究组在对照组的基础上联合健神利水颗粒治疗,两组均治疗14 d。比较两组疗效、美国国立卫生研究院卒中量表(NIHSS)评分、超敏C反应蛋白(hs-CRP)、S-100β蛋白、白细胞介素-1β(IL-1β)、血肿体积、脑水肿体积、收缩期峰值血流速度、平均血流速度、脑血流量及不良反应发生情况。结果研究组临床总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗后NIHSS评分均较治疗前下降,且研究组低于对照组,差异均有统计学意义(均P<0.05)。两组治疗后平均血流速度、收缩期峰值血流速度、脑血流量均较治疗前升高,且研究组高于对照组,差异均有统计学意义(均P<0.05)。两组治疗后hs-CRP、S-100β蛋白、IL-1β均较治疗前降低,且研究组低于对照组,差异均有统计学意义(均P<0.05)。两组治疗后血肿体积、脑水肿体积均较治疗前缩小,且研究组小于对照组,差异均有统计学意义(均P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论健神利水颗粒联合呋塞米治疗脑出血继发性脑水肿,可促进血肿体积、脑水肿体积缩小,改善脑部血流,降低脑组织炎症反应及过氧化损伤,减轻脑组织损伤,疗效肯定。Objective To investigate the clinical effect of Jianshi Lishui Granules combined with Furosemide in the treatment of secondary cerebral edema after cerebral hemorrhage.Methods A total of 100 patients with secondary cerebral edema after cerebral hemorrhage admitted to the First Affiliated Hospital of Guangxi University of Chinese Medicine from April 2017 to April 2020 were selected and they were divided into control group and study group according to random number table method,with 50 cases in each group.The control group was treated with Furosemide,and the study group was treated with Jianshi Lishui Granules on the basis of the control group.Both groups were treated for 14 days.The efficacy,the United States national institutes of health stroke scale(NIHSS)score,hypersensitive C-reactive protein(hs-CRP),S-100βprotein,interleukin-1β(IL-1β),hematoma volume,cerebral edema volume,peak systolic blood flow velocity,average blood flow velocity,cerebral blood flow and incidence of adverse reactions were compared between the two groups.Results The clinical total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,NIHSS scores in both groups were decreased compared with before treatment,and those in the study group were lower than those in the control group,with statistical significance(all P<0.05).After treatment,average blood flow velocity,peak systolic blood flow velocity and cerebral blood flow in both groups were increased compared with before treatment,and those in the study group were higher than those in the control group,with statistical significance(all P<0.05).After treatment,hs-CRP,S-100βprotein and IL-1βwere decreased in both groups compared with before treatment,and those in the study group were lower than those in the control group,with statistical significance(all P<0.05).After treatment,hematoma volume and cerebral edema volume in both groups were decreased compared with before treatment,and the those in t

关 键 词：健神利水颗粒 呋塞米 脑出血继发性脑水肿 临床疗效 

分 类 号：R743[医药卫生—神经病学与精神病学]