多西紫杉醇在乳腺癌根治术后化疗中的应用效果及安全性观察  

Application effect and safety of Docetaxel in postoperative chemotherapy after radical mastectomy

作　　者：袁乐[1] 宛新安[1] 周勤[1] YUAN Le;WAN Xin’an;ZHOU Qin(Department of Radiotherapy,the Second People’s Hospital of Wuhu City,Anhui Province,Wuhu 241000,China)

机构地区：[1]安徽省芜湖市第二人民医院放疗科,安徽芜湖241000

出　　处：《中国医药导报》2021年第14期107-110,共4页China Medical Herald

摘　　要：目的探讨多西紫杉醇在乳腺癌根治术后化疗中的应用效果及安全性。方法选取2015年1月—2017年1月安徽省芜湖市第二人民医院行乳腺癌根治术的乳腺癌患者60例为研究对象。按照随机数表法将患者分为两组,每组30例。对照组给予表柔比星联合环磷酰胺治疗,观察组在对照组的基础上给予多西紫杉醇治疗。比较两组患者临床疗效、毒副作用发生程度。治疗后,通过电话随访3年,若患者死亡则停止随访,观察两组治疗后1~3年的生存率。结果观察组总有效率及疾病控制率高于对照组,差异有统计学意义(P<0.05)。两组治疗后消化系统毒副作用发生程度比较,差异无统计学意义(P>0.05)。治疗后1、2年,两组生存率比较,差异无统计学意义(P>0.05);治疗后3年,观察组生存率高于对照组,差异有统计学意义(P<0.05)。结论乳腺癌根治术后使用多西紫杉醇化疗效果显著,安全性高,预后佳。Objective To investigate the application effect and safety of Docetaxel in chemotherapy after radical mastectomy.Methods Sixty patients with breast cancer who underwent radical mastectomy in the Second People’s Hospital of Wuhu City,Anhui Province from January 2015 to January 2017 were selected as research subjects.They were divided into two groups according to random number table method,with 30 cases in each group.Control group was given Epirubicin combined with Cyclophosphamide,and observation group was given Docetaxel on the basis of control group.The clinical efficacy and the occurrence degree of toxic side effects were compared between two groups.After treatment,the patients were followed up for three years by telephone.If the patients died,the follow-up was stopped.The survival rates of one to three years after treatment were observed between two groups.Results The total effective rate and disease control rate of observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the occurrence degree of toxic side effects in digestive system between two groups after treatment(P>0.05).One and two years after treatment,there were no differences in survival rates between two groups(P>0.05);three years after treatment,the survival rate of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).Conclusion Docetaxel chemotherapy after radical mastectomy has significant effect,high safety and good prognosis.

关 键 词：多西紫杉醇 表柔比星 环磷酰胺 乳腺癌根治术 化疗 毒副作用 安全性 

分 类 号：R737.9[医药卫生—肿瘤]