双针微波消融结合经导管动脉化疗栓塞治疗巨大原发性肝癌有效性分析  

Effectiveness analysis of double needle microwave ablation combined with transcatheter arterial chemoembolization for hepatocel-lula carcinoma

作　　者：刘芳[1] 季良[1] 姜海燕[1] 陈男男 陈志赫 宋微[1] 杜宁[2] LIU Fang;JI Liang;JIANG Haiyan;CHEN Nannan;CHEN Zhihe;SONG Wei;DU Ning(Department of Infection,the Central Hospital of Jiamusi City in Heilongjiang Province,Jiamusi 154002,China;School of Public Health,Jiamusi University,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院感染科,黑龙江佳木斯154002 [2]佳木斯大学公共卫生学院,黑龙江佳木斯154002

出　　处：《中国现代医生》2021年第13期17-20,共4页China Modern Doctor

摘　　要：目的探讨双针微波消融结合经导管动脉化疗栓塞治疗巨大原发性肝癌的有效性。方法选取我院2017年1月至2018年8月收治的80例巨大原发性肝癌患者作为主要研究对象,将患者随机分为观察组与对照组,每组各40例,对照组患者给予肝癌经导管动脉化疗栓塞介入治疗,观察组患者给予双针微波消融结合经导管动脉化疗栓塞治疗。对比两组患者的近期治疗效果、远期生存率、肿瘤标志物和不良反应情况。结果两组患者治疗30 d后,对照组患者治疗总有效率为42.5%,观察组为75.0%,观察组明显高于对照组(P<0.05);观察组患者在半年、1年和2年的生存率明显高于对照组(P<0.05),观察组患者的平均存活时间明显长于对照组(P<0.05);通过对比两组患者治疗前与治疗30 d后肿瘤标志物水平发现,治疗前两组患者AFP水平比较,差异无统计学意义(P>0.05),治疗30 d后,观察组AFP水平明显低于对照组(P<0.05);两组患者放射性肝病、胃肠道反应、肝功能受损、骨髓抑制、肝区疼痛不良反应发生率比较,差异无统计学意义(P>0.05)。结论针对巨大原发性肝癌患者应用双针微波消融结合经导管动脉化疗栓塞治疗与常规介入治疗相比,能够提升患者的近远期生存率,治疗效果更好,而且能够减少患者体内的肿瘤标志物,不增加不良反应,安全性好,值得临床应用推广。Objective To explore the effectiveness of double needle microwave ablation combined with transcatheter arterial chemoembolization in the treatment of hepatocel-lula carcinoma(HCC).Methods A total of 80 patients with HCC admitted to our hospital from January 2017 to August 2018 were selected as the main research objects.The patients were randomly divided into the observation group and the control group,with 40 cases in each group.The patients in the control group were given transcatheter arterial chemoembolization,while the patients in the observation group were given double needle microwave ablation combined with transcatheter arterial chemoembolization.The short-term therapeutic effect,long-term survival rate,tumor markers and adverse reactions of the two groups of patients were compared.Results 30 days after treatment,the total therapeutic effective rate was 42.5%in the control group,which was significantly lower than 75.0%in the observation group(P<0.05).The survival rates were significantly higher in the observation group half a year,one year and two years later than those in the control group(P<0.05),and the mean survival time was significantly longer in the observation group than that in the control group(P<0.05).By comparing the levels of tumor markers before treatment and 30 days after treatment,there was no significant difference in armor embryo protein(AFP)level between the two groups before treatment(P>0.05),While 30 days after treatment,AFP level was significantly lower in the observation group than that in the control group(P<0.05).There were no significant differences between the observation group and the control group in the incidences of adverse reactions of radiation liver disease,gastrointestinal reactions,liver function damage,bone marrow suppression and liver pain(P>0.05).Conclusion Compared with conventional interventional therapy,double needle microwave ablation combined with transcatheter arterial chemoembolization can improve the short-term and long-term survival rate of patients with HCC,

关 键 词：双针微波消融 经导管动脉化疗栓塞 原发性肝癌 有效性 生存率 

分 类 号：R735.7[医药卫生—肿瘤]