Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths:An ecological integrative approach  

作　　者：Dimitrios T Papadimitriou Alexandros K Vassaras Michael F Holick 

机构地区：[1]Pediatric-Adolescent Endocrinology and Diabetes,Athens Medical Center,Marousi 15125,Greece [2]Endocrine Unit,Aretaieion University Hospital,Athens 11528,Greece [3]Neurology Department,Papageorgiou Hospital,Aristotle University of Thessaloniki,Thessaloniki 56429,Greece [4]Neuroimmunology Department,Democritus University of Thrace,Alexandroupoli 68100,Greece [5]Section Endocrinology,Nutrition and Diabetes,Department of Medicine,Boston University Medical Center,Boston,MA 02118,United States

出　　处：《World Journal of Virology》2021年第3期111-129,共19页世界病毒学杂志

摘　　要：BACKGROUND Vitamin D population status may have possible unappreciated consequences to the coronavirus disease 2019(COVID-19)pandemic.Αsignificant association between vitamin D sufficiency and reduction in clinical severity and inpatient mortality from COVID-19 disease has recently been shown,while a recent study has claimed lower COVID-19 cases in European countries with a better vitamin D status.Low serum 25-hydroxyvitamin-D[25(OH)D]was identified as an independent risk factor for COVID-19 infection and hospitalization,and administration of 0.532 mg(21280 IU)of calcifediol or 25(OH)D,followed by 0.266 mg on days 3 and 7 and then weekly until discharge or intensive care unit admission significantly reduced the need for intensive care unit treatment.AIM To elucidate the role of vitamin D European population status in the COVID-19 pandemic,data from the Worldometer were analyzed.METHODS Linear regression explored the correlation between published representativestandardized population vitamin D concentrations and the number of total cases/million(M),recovered/M,deaths/M and serious-critically ill/M from COVID-19 for 26 European countries populated>4 M(Worldometer).Life expectancy was analyzed with semi-parametric regression.Weighted analysis of variance/analysis of covariance evaluated serious-critical/M and deaths/M by the vitamin D population status:Deficient<50,insufficient:50-62.5,mildly insufficient>62.5-75 and sufficient>75 nmol/L,while controlling for life expectancy for deaths/M.Statistical analyses were performed in XLSTAT LIFE SCIENCE and R(SemiPar Library).RESULTS Linear regression found no correlation between population vitamin D concentrations and the total cases-recovered/M,but negative correlations predicting a reduction of 47%-64%-80%in serious-critical illnesses/M and of 61%-82%-102.4%in deaths/M further enhanced when adapting for life expectancy by 133-177-221%if 25(OH)D concentrations reach 100-125-150 nmol/L,sustained on August 15,2020,indicating a truthful association.Weighted analysis of vari

关 键 词：COVID-19 SARS-CoV-2 Vitamin D status Vitamin D concentrations 25-hydroxyvitamin-D Immunity 

分 类 号：G63[文化科学—教育学]