New insights into renal lipid dysmetabolism in diabetic kidney disease  

作　　者：Alla Mitrofanova George Burke Sandra Merscher Alessia Fornoni 

机构地区：[1]Peggy and Harold Katz Family Drug Discovery Center,University of Miami,Miller School of Medicine,Miami,FL 33136,United States [2]Katz Family Division of Nephrology and Hypertension,Department of Medicine,University of Miami,Miller School of Medicine,Miami,FL 33136,United States [3]Department of Surgery,University of Miami,Miller School of Medicine,Miami,FL 33136,United States [4]Diabetes Research Institute,University of Miami,Miller School of Medicine,Miami,FL 33136,United States

出　　处：《World Journal of Diabetes》2021年第5期524-540,共17页世界糖尿病杂志（英文版）（电子版）

基　　金：the National Institute of Health(Research in Dr.Alessia Fornoni’s laboratory),No.R01DK117599,No.R01DK104753,No.R01CA227493,No.U54DK083912,No.UM1DK100846,and No.U01DK116101;the Miami Clinical Translational Science Institute,No.UL1TR000460;and the Chernowitz Medical Research Foundation(Mitrofanova A and Burke G),No.GR016291.

摘　　要：Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs,including the kidney.Research suggests that impaired cholesterol metabolism,increased lipid uptake or synthesis,increased fatty acid oxidation,lipid droplet accumulation and an imbalance in biologically active sphingolipids(such as ceramide,ceramide-1-phosphate and sphingosine-1-phosphate)contribute to the development of diabetic kidney disease(DKD).Currently,the literature suggests that both quality and quantity of lipids are associated with DKD and contribute to increased reactive oxygen species production,oxidative stress,inflammation,or cell death.Therefore,control of renal lipid dysmetabolism is a very important therapeutic goal,which needs to be archived.This article will review some of the recent advances leading to a better understanding of the mechanisms of dyslipidemia and the role of particular lipids and sphingolipids in DKD.

关 键 词：Diabetes LIPIDS Free fatty acids ATP-binding cassette transporters sub-class A Sterol-O-acyltransferase 1 CD36 SPHINGOLIPIDS Sphingomyelin phosphodiesterase acid-like 3b Diabetic kidney disease 

分 类 号：R692.9[医药卫生—泌尿科学] R587.2[医药卫生—外科学]