Idiopathic mesenteric phlebosclerosis associated with long-term oral intake of geniposide  

作　　者：Yang Wen You-Wei Chen Ai-Hong Meng Ming Zhao Song-Hua Fang Yan-Qing Ma 

机构地区：[1]Department of Radiology,Zhejiang Provincial People's Hospital,People's Hospital of Hangzhou Medical College,Hangzhou 310014,Zhejiang Province,China [2]Department of Gastroenterology,Zhejiang Provincial People's Hospital,People's Hospital of Hangzhou Medical College,Hangzhou 310014,Zhejiang Province,China [3]Department of Gastroenterology,Hangzhou Yuhang District Hospital of Traditional Chinese Medicine,Hangzhou 311100,Zhejiang Province,China [4]Department of Pathology,Zhejiang Provincial People's Hospital,People's Hospital of Hangzhou Medical College,Hangzhou 310014,Zhejiang Province,China

出　　处：《World Journal of Gastroenterology》2021年第22期3097-3108,共12页世界胃肠病学杂志（英文版）

基　　金：Supported by the Fund of Medical and Health Research Projects of Health Commission of Zhejiang Province,No.2018KY247 and No.2019KY035.

摘　　要：BACKGROUND Idiopathic mesenteric phlebosclerosis(IMP)is a rare disease,and its etiology and risk factors remain uncertain.AIM To investigate the possible influence of Chinese herbal liquid containing geniposide on IMP.METHODS The detailed formula of herbal liquid prescriptions of all patients was studied,and the herbal ingredients were compared to identify the toxic agent as a possible etiological factor.Abdominal computed tomography(CT)and colonoscopy images were reviewed to determine the extent and severity of mesenteric phlebosclerosis and the presence of findings regarding colitis.The disease CT score was determined by the distribution of mesenteric vein calcification and colon wall thickening on CT images.The drinking index of medicinal liquor was calculated from the daily quantity and drinking years of Chinese medicinal liquor.Subsequently,Spearman’s correlation analysis was conducted to evaluate the correlation between the drinking index and the CT disease score.RESULTS The mean age of the 8 enrolled patients was 75.7 years and male predominance was found(all 8 patients were men).The patients had histories of 5-40 years of oral Chinese herbal liquids containing geniposide and exhibited typical imaging characteristics(e.g.,threadlike calcifications along the colonic and mesenteric vessels or associated with a thickened colonic wall in CT images).Calcifications were confined to the right-side mesenteric vein in 6 of the 8 patients(75%)and involved the left-side mesenteric vein of 2 cases(25%)and the calcifications extended to the mesorectum in 1 of them.The thickening of colon wall mainly occurred in the right colon and the transverse colon.The median disease CT score was 4.88(n=7)and the median drinking index was 5680(n=7).After Spearman’s correlation analysis,the median CT score of the disease showed a significant positive correlation with the median drinking index(r=0.842,P<0.05).CONCLUSION Long-term oral intake of Chinese herbal liquid containing geniposide may play a role in the pathogenesis of IMP.

关 键 词：Idiopathic mesenteric phlebosclerosis Phlebosclerotic colitis Chinese herbal liquid GENIPOSIDE COLONOSCOPY Computed tomography 

分 类 号：R285.6[医药卫生—中药学]