宫颈癌患者行腹腔镜子宫广泛性切除术后肿瘤标志物检测的意义  

Significance of detection of tumor markers after laparoscopic radical hysterectomy for cervical cancer

作　　者：黑江荣[1] 解雁飞[1] 张利平[1] HEI Jiang-rong;JIE Yan-fei;ZHANG Li-ping(Department of Obstetrics,Yan’an University Affiliated Hospital,Yan’an 716000,China)

机构地区：[1]陕西延安大学附属医院产科,延安716000

出　　处：《中国肿瘤临床与康复》2021年第5期528-531,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨子宫颈癌患者行腹腔镜下子宫广泛性切除术后肿瘤标志物的检测意义。方法选取2019年1月至2020年1月间延安大学附属医院收治的96例子宫颈癌患者,按患者意愿分为研究组和对照组,每组48例。对照组患者采用传统开腹子宫切除术,研究组患者采用腹腔镜下子宫广泛性切除术,术后检测并比较两组患者血清鳞状细胞癌抗原(SCC-Ag)、糖类抗原125(CA125)和癌胚抗原(CEA)指标。结果两组患者左侧、右侧主韧带切除长度、阴道切除长度和淋巴结切除数量比较,差异均无统计学意义(P>0.05)。研究组患者术后排尿功能恢复时间、术后肛门排气时间、术中出血量和手术时间均短于对照组,差异均有统计学意义(均P<0.05)。研究组患者并发症总发生率为29.2%,低于对照组的54.2%,差异有统计学意义(P<0.05)。治疗后,两组患者SCC-Ag、CA125和CEA水平均降低,且研究组均低于对照组,差异均有统计学意义(均P<0.05)。结论腹腔镜下子宫广泛性切除术利于加快子宫颈癌患者术后康复,减少术中出血量,手术时间较短,肿瘤标志物水平均低于传统开腹子宫切除术。Objective To investigate the significance of detection of tumor markers after laparoscopic radical hysterectomy for cervical cancer.Methods From January 2019 to January 2020,96 patients with cervical cancer were selected at Yan’an University Affiliated Hospital.They were classified into a study group and a control group based on their intention.The study group underwent laparoscopic radical hysterectomy and the control group underwent conventional abdominal hysterectomy.Serum squamous cell carcinoma associated antigen(SCC-Ag),carbohydrate antigen-125(CA-125),and carcinoembryonic antigen(CEA)after the operation were compared between the two groups.Results There was no significant difference in the length of the left and right main ligament resected,the length of vaginal resected,and the number of lymph node resected(P>0.05).The time to postoperative recovery of urinary function,time to postoperative anal exhaust,intraoperative blood loss and the duration of operation was shorter in the study group than in the control group(all P<0.05).The overall incidence of complications was 29.2%in the study group which was lower than 54.2%of the control group(P<0.05).The levels of SCC-Ag,CA125 and CEA decreased in both groups in both groups and these levels were lower in the study group than in the control group(all P<0.05).Conclusion Laparoscopic radical hysterectomy may speed up the recovery after operation and reduce intraoperative blood loss in patients with cervical cancer with a relatively short duration of surgery.Tumor marker levels are comparatively low compared with conventional abdominal hysterectomy.

关 键 词：子宫颈肿瘤 开腹子宫切除术 腹腔镜下子宫广泛性切除术 淋巴结转移 肿瘤标记物 机体免疫功能 

分 类 号：R737.3[医药卫生—肿瘤]