乌鲁木齐妇女宫颈病变与高危型人乳头状瘤病毒负荷量关系研究  

Relationship between cervical lesions and high risk human papillomavirus load in Urumqi women

作　　者：姚立丽[1] 袁敏[1] 周萍[1] 戚婷婷[1] 朱晓南 袁建林[1] YAO Li-li;YUAN Min;ZHOU Ping;QI Ting-ting;ZHU Xiao-nan;YUAN Jian-lin(Department of Gynecoloy,Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院妇科,新疆乌鲁木齐830011

出　　处：《哈尔滨医科大学学报》2021年第1期59-63,共5页Journal of Harbin Medical University

基　　金：乌鲁木齐市科学技术计划项目(P101310004)。

摘　　要：目的探讨乌鲁木齐妇女高危型人乳头状瘤病毒(HR-HPV)感染状况与宫颈病变的相关性。方法应用第二代杂交捕获实验(HC-Ⅱ)方法、宫颈液基细胞学检测(TCT)法开展宫颈癌筛查,对于HR-HPV感染阳性或者液基细胞学(TCT)诊断≥ASC者进行阴道镜及宫颈组织病理活检。结果(1)2300例女性中,HR-HPV检测阳性者385例,感染率为16.74%。随着宫颈病变程度的加重,HR-HPV感染率升高,不同级别的宫颈病变中HR-HPV感染率差别具有统计学意义(χ^(2)=936.304,P=0.000)。(2)在HR-HPVDNA负荷量>500时,宫颈病变的阳性率明显增高(P<0.05),当HR-HPVDNA负荷量>1000时,宫颈癌的阳性率明显增高(P<0.05)。HSIL及宫颈癌在HPV-DNA负荷量>1时的诊断阳性率较<1时显著升高(P<0.05)。(3)HPV-DNA检测、TCT检测两种方法对宫颈病变检出的灵敏度、阴性、阳性预测值方面差异具有统计学意义(P<0.001)。结论乌鲁木齐妇女HR-HPV负荷量随宫颈病变的严重程度而增加,HR-HPV检测可以作为新疆地区宫颈癌初筛的首要方法。Objective To investigate the correlation between high risk human papillomavirus(HR-HPV)infection and cervical lesions in Urumqi women.Methods The second-generation hybrid capture test(HC-Ⅱ)method and cervical fluid-based cytology(TCT)method were used for cervical cancer screening.Those with positive HR-HPV infection or liquid-based cytology(TCT)diagnosis≥ASC A colposcopy and cervical histopathological biopsy were performed.Results Among 2300 women,385 cases were positive for HR-HPV,and the infection rate was 16.74%.With the severity of cervical lesions,the HR-HPV infection rate increased,and the difference in HR-HPV infection rates between different levels of cervical lesions was statistically significant(χ^(2)=940.304,P=0.000).In the HPV-DNA load>500,the positive rate of cervical precancerous lesions increased significantly(P<0.05),and when the HPV-DNA load was>1000,the positive rate of cervical cancer increased significantly(P<0.05).The positive rate of diagnosis of HSIL and cervical cancer with HPV-DNA load>1 was significantly higher than that with<1(P<0.05).HPV-DNA test and TCT test had statistically significant differences in the sensitivity,negative,and positive predictive value of cervical lesion detection(P<0.001).Conclusion Urumqi women’s HR-HPV load varies with the severity of cervical lesions.The HR-HPV test can be used as the primary method for the initial screening of cervical cancer.

关 键 词：病毒负荷量 高危型人乳头状瘤病毒 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]