童年期虐待与单胺氧化酶A基因多态性在青少年反社会行为中的交互作用  

Research progress for the interaction of child abuse and monoamine oxidase A gene on antisocial behavior among adolescents

作　　者：袁梦园 苏普玉[1] YUAN Mengyuan;SU Puyu(Department of Maternal,Child and Adolescent Health,School of Public Health,Anhui Medical University/Key Laboratory of Population Health Across Life Cycle,Ministry of Education of the People's Republic of China/Anhui Pro-vincial Key Laboratory of Population Health and Aristogenics,Hefei 230032,China)

机构地区：[1]安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室/人口健康与优生安徽省重点实验室,合肥230032

出　　处：《中国学校卫生》2021年第5期792-795,800,共5页Chinese Journal of School Health

基　　金：国家自然科学基金面上项目(81874268)。

摘　　要：青少年反社会行为给个人健康、家庭和社会都带来沉重的负担,引起了公众的广泛关注。目前,大多数研究已证实童年期虐待、单胺氧化酶A基因与反社会行为之间存在关联。然而,关于童年期虐待与单胺氧化酶A基因交互作用与反社会行为之间的关联性尚存在争议。本文旨在对童年期虐待与单胺氧化酶A基因交互作用与青少年反社会行为的最新研究成果及其可能的作用机制进行综述,发现童年期虐待与单胺氧化酶A基因可能通过影响大脑中特定的神经环路、改变情绪调节功能等交互作用于反社会行为。此外,本综述剖析了当前研究结果不一致的可能原因,为今后研究指明方向,也为青少年反社会行为的预防控制提供科学依据。Antisocial behavior among adolescents caused a severe burden on individuals, families and society, which has aroused a global concern. At present, the association of child abuse and monoamine oxidase A gene with antisocial behavior has been confirmed in most studies. However, there was a controversy about the interaction of child abuse and monoamine oxidase A gene on antisocial behavior. This study aimed to review latest findings and mechanisms of the interaction of child abuse and monoamine oxidase A gene on antisocial behavior among adolescents. The result showed that the child abuse interacted with monoamine oxidase A gene in antisocial behavior by influencing the specific neural circuits in the brain and changing the function of mood regulation, etc. Additionally, this study analyzed potential reasons for the inconsistency of current study findings, and identified the directions for future research. Moreover, this review was to provide a scientific basis for the prevention and control of adolescent antisocial behavior.

关 键 词：虐待儿童 基因 社会行为 青少年 精神卫生 

分 类 号：R179[医药卫生—妇幼卫生保健] G444[医药卫生—公共卫生与预防医学]