[^(18)F]-氟代脱氧葡萄糖正电子发射型计算机断层显像与计算机断层扫描显像最大标准化摄取值与乳腺浸润性导管癌临床病理特征的相关性研究  

Correlation between maximum standardized uptake value of ^(18 )F-fluorodexoxyglucose position emission tomography/CT and clinicopathological features in breast invasive ductal carcinoma

作　　者：杨志[1] 柴华[1] 仇冰清 韦琳琳 罗煜 杨彩娟[1] 李宁[1] 肖国有[1] YANG Zhi;CHAI Hua;QIU Bing-qing;WEI Lin-lin;LUO Yu;YANG Cai-juan;LI Ning;XIAO Guo-you(Department of Nuclear Medicine,Guangxi Medical University Affiliated Tumor Hospital&Guangxi Research Center of Imaging Medicine and Clinical Medicine&Guangxi Key Clinical Specialty Department of Imaging Medicine&Guangxi Medical University Affiliated)

机构地区：[1]广西医科大学附属肿瘤医院核医学科/广西影像医学临床医学研究中心/广西临床重点专科(医学影像科)/广西医科大学附属肿瘤医院优势培育学科(医学影像学科),南宁市530021

出　　处：《广西医学》2021年第7期789-793,共5页Guangxi Medical Journal

基　　金：国家自然科学基金(81760533);广西医疗卫生适宜技术开发与推广应用项目(S201633);广西医药卫生科研课题(Z2016472、Z20170436、Z20190559、Z20190595、Z20200403、Z20200445、Z20200545);广西医科大学青年科学基金(GXMUYSF201819);广西医科大学教师教学能力发展项目(30)。

摘　　要：目的探讨[^(18)F]-氟代脱氧葡萄糖(^(18)F-FDG)正电子发射型计算机断层显像与计算机断层扫描(PET/CT)最大标准化摄取值(SUV max)与乳腺浸润性导管癌临床病理特征的相关性。方法回顾性分析58例乳腺浸润性导管癌患者的临床资料,所有患者术前均行^(18)F-FDG PET/CT显像。采用Pearson相关分析SUV max与病灶大小及Ki-67水平的关系,采用协方差分析不同病理参数[雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER2)及Ki-67]、不同病理亚型、不同转移特征乳腺癌患者SUV max的差异。结果乳腺癌病灶SUV max与病灶大小、Ki-67水平均呈正相关(均P<0.05)。ER、PR阴性者的SUV max高于阳性者,HER2阴性及不确定者的SUV max低于HER2阳性者(均P<0.05)。4种病理亚型乳腺癌患者的SUV max差异有统计学意义,其中Luminal A型的SUV max低于非Luminal A型(均P<0.05)。有同侧腋窝淋巴结转移和远处转移者SUV max分别高于无同侧腋窝淋巴结转移和无远处转移者(均P<0.05)。结论^(18)F-FDG PET/CT显像SUV max增高与乳腺癌侵袭性病理亚型及转移有关,可为乳腺癌治疗方案的选择及预后评估提供影像学依据。Objective To investigate the correlation of maximum standardized uptake value(SUV max)of^(18)F-fluorodexoxyglucose(18 F-FDG)position emission tomography(PET)/CT with clinicopathological characteristics in breast invasive ductal carcinoma.Methods The clinical data of 58 patients with breast invasive ductal cancer were analyzed retrospectively,and all patients received^(18)F-FDG PET/CT imaging before operation.Pearson correlation analysis was applied to the relationship of SUV max with focal size and Ki-67 level.Covariance analysis was performed on the differences in SUV max among breast cancer patients with different pathological parameters(estrogen receptor[ER],progesterone receptor[PR],human epidermal growth factor receptor 2[HER2],and Ki-67),with different pathological subtypes,or with different metastasis features.Results SUV max of breast cancer lesions positively correlated with focal size and Ki-67 level(all P<0.05).Subjects with ER or PR negative had higher SUV max than positive subjects(P<0.05),subjects with HER2 negative or uncertain subjects experienced decreased SUV max than subjects with HER2 positive(all P<0.05).Patients with breast cancer of four different pathological subtypes exhibited statistically significant difference in SUV max,among them,Luminal A breast cancer had lower SUV max than non-Luminal A breast cancer(all P<0.05).Subjects with ipsilateral axillary node metastases and distal metastases had higher SUV max than those without ipsilateral axillary node metastases and distal metastases respectively(all P<0.05).Conclusion The increased SUV max of^(18)F-FDG PET/CT imaging is related to the invasive pathological subtype and metastasis of breast cancer,which provides the imaging basis for treatment regimen option and prognosis evaluation in breast cancer.

关 键 词：乳腺癌 正电子发射型计算机断层显像与计算机断层扫描 [^(18)F]-氟代脱氧葡萄糖 最大标准化摄取值 临床病理 相关性 

分 类 号：R737.9[医药卫生—肿瘤]