血清超敏C反应蛋白与伴躯体症状抑郁症的临床相关性研究  

Clinical correlation between serum hypersensitive C-reactive protein and depression with somatic symptoms

作　　者：庄二阳 乔娟 赵后锋 孟俊廷 耿德勤 ZHUANG Eryang;QIAO Juan;ZHAO Houfeng(Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University, Xuzhou 221000, China)

机构地区：[1]徐州医科大学附属徐州东方医院,江苏徐州221000 [2]徐州医科大学附属医院

出　　处：《精神医学杂志》2021年第2期140-144,共5页Journal of Psychiatry

基　　金：徐州市科技计划项目(编号:KC18172)。

摘　　要：目的探讨血清超敏C反应蛋白(hs-CRP)与伴躯体症状抑郁症的相关性及其临床意义。方法选取抑郁症患者120例作为研究组,根据症状自评量表(SCL-90)躯体化因子分是否大于2分,将研究组分为伴躯体症状组和不伴躯体症状组各60例。另选取60名健康人员作为对照组。入组时采用汉密尔顿抑郁量表(HAMD-24)评定各组病情。伴与不伴躯体症状组应用盐酸度洛西汀口服治疗6周,并采用免疫荧光法测定各组血清hs-CRP水平,并通过组间、组内统计分析抑郁症患者躯体症状与hs-CRP的相关性。结果研究组治疗后第1、2、4、6周末血清hs-CRP水平、HAMD评分均较治疗前降低(P<0.05)。伴躯体症状组治疗前及治疗后第1、2、4、6周末血清hs-CRP水平均高于不伴躯体症状组和对照组(P<0.05),不伴躯体症状组治疗前及治疗后第1、2、4周末血清hs-CRP水平均高于对照组(P<0.05)。伴躯体症状组血清hs-CRP水平与HAMD总分及躯体症状、睡眠障碍、胃肠道症状、全身症状因子分均呈正相关(P<0.05)。结论伴有躯体症状的抑郁症患者血清hs-CRP水平升高;血清hs-CRP水平与抑郁症患者的躯体症状相关,可以从某种程度上反映抑郁症患者躯体症状的严重程度。Objective To explore the correlation between serum hypersensitive C-reactive protein(hs-CRP)and depression with somatic symptoms and its clinical significance.Methods A total of 120 patients with depression in study group were selected and divided into group with somatic symptoms(60 cases,somatization factor score>2)and group without somatic symptoms(60 cases,somatization factor score≤2)according to the somatization factor score of Symptom Checklist-90(SCL-90).60 healthy controls were selected as control group.Hamilton Depression Scale(HAMD-24)was used to assess the condition of each group.The study group took duloxetine hydrochloride for 6 weeks,and the serum level of hs-CRP in each group was determined by immunofluorescence method.Correlations between somatic symptoms and hs-CRP in patients with depression were conducted through inter-group and intra-group analyses.Results At the ends of the 1st,2nd,4th and 6th weeks of treatment,the serum levels of hs-CRP and the total scores of HAMD in study group decreased significantly compared with those before treatment(P<0.05).Before treatment and at the ends of the 1st,2nd,4th and 6th weeks of treatment,the serum levels of hs-CRP in group with somatic symptoms were significantly higher than those in group without somatic symptoms and control group(P<0.05).Before treatment and at the ends of the 1st,2nd,4th weeks of treatment,the serum levels of hs-CRP in group without somatic symptoms were significantly higher than those in control group(P<0.05).In group with somatic symptoms,the serum level of hs-CRP was positively correlated with the total score and factor scores of somatic symptoms,sleep disturbance,gastrointestinal symptoms and constitutional symptoms in HAMD(P<0.05).Conclusion The serum level of hs-CRP in depressive patients with somatic symptoms is higher,which is related to their somatic symptoms and can reflect the severity of somatic symptoms to some extent.

关 键 词：抑郁症 躯体症状 超敏C反应蛋白 盐酸度洛西汀 

分 类 号：R749.4[医药卫生—神经病学与精神病学]