MicroRNA-429在妇科恶性肿瘤中的研究进展  

Research progress of MicroRNA-429 in gynecological malignant tumors

作　　者：李栗扬 徐鹏[1] 王蓓蒂[1] 高爽 郭钰 匡野[1] LI Li-yang;XU Peng;WANG Bei-di;GAO Shuang;GUO Yu;KUANG Ye(Department of Gynecology and Obstetrics,the Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,黑龙江哈尔滨150086

出　　处：《中华全科医学》2021年第6期1013-1016,1034,共5页Chinese Journal of General Practice

基　　金：吴阶平医学基金会临床科研课题项目(320675018061)。

摘　　要：妇科恶性肿瘤是威胁女性健康的难题,早期诊断及治疗对于其预后来说意义重大。微小核糖核酸(microRNA,miRNA)是参与细胞转录后调控的小型非编码RNA,在细胞正常生理过程及肿瘤发生发展中起关键作用。MicroRNA-429(miR-429)可抑制相关转录遏制物锌指E盒结合同源框1(Zinc E-box-binding homobox 1,ZEB1)和ZEB2的表达影响肿瘤的进展及转移,并通过调控Slug基因的表达,影响E-钙黏蛋白和Snail蛋白等的表达,进而调控肿瘤中的上皮间质转化(epithelial-mesenchymal transition, EMT),影响着肿瘤的迁移侵袭、预后以及药物敏感性。miR-429在卵巢癌(ovarian cancer)中起到肿瘤促进作用且不利于预后,但其低表达与患者生存率低相关,并且在卵巢癌腹水中发现了miR-429的差异表达,具有潜在临床诊断意义;在宫颈癌(cervical cancer)中起到肿瘤抑制作用;在子宫内膜癌(endometrial cancer)中起到肿瘤促进作用,并且可能具有潜在的诊断价值。现将关于miR-429及其在妇科恶性肿瘤中作用的相关文献进行综述,结合肿瘤发生、侵袭等多方面因素进行讨论,综合分析miR-429在妇科恶性肿瘤的意义,并为进一步研究其在临床应用中的意义提供参考。Gynecological malignant tumors is a problem that threatens women’s health, of which early diagnosis and treatment are of great significance to the prognosis. MicroRNA(miRNA) is a small non-coding RNA involved in post-transcriptional regulation of cells, which plays a key role in the normal physiological processes of cells and the development of tumors. MicroRNA-429(miR-429) can inhibit the expression of zinc E-box-binding homobox 1(ZEB1) and ZEB2, which affects tumor progression and metastasis, and regulates Slug Gene expression in order to affects the expression of E-cadherin and Snail protein, and regulates the epithelial-mesenchymal transition(EMT) in tumors, which affects tumor migration, invasion, prognosis, and drug sensitivity. MiR-429 plays a tumor-promoting role in ovarian cancer and is not conducive to the prognosis, but its low expression is associated with low patient survival rates, and the differential expression of miR-429 was found in the ascites of ovarian cancer patients, which has potential clinical diagnostic significance. It plays a role in tumor suppression in cervical cancer role;plays a tumor-promoting role in endometrial cancer, and may have potential diagnostic value in endometrial cancer.The related literature on miR-429 and it’s role in gynecological malignancies is reviewed, combined with tumor occurrence, invasion and other factors to discuss, comprehensively analyze the significance of miR-429 in gynecological malignancies, and for the further study significance in clinical application provides reference.

关 键 词：微小核糖核酸-429 上皮-间质转化 卵巢癌 宫颈癌 子宫内膜癌 

分 类 号：R737.3[医药卫生—肿瘤] R730[医药卫生—临床医学]