载药脂质微泡推进智能化超声医学技术的研究进展  

Advances of Research on Drug-Loaded Lipid Microbubbles Promoting the Development of Intelligent Ultrasonic Medical Technology

作　　者：龙朦朦 刘东 杨芳[1] 顾宁[1] LONG Mengmeng;LIU Dong;YANG Fang;GU Ning(School of Biological Sciences and Medical Engineering,Southeast University,Nanjing 210096,China;School of Biological and Pharmaceutical Engineering,West Anhui University,Lu'an 237012,China)

机构地区：[1]东南大学生物科学与医学工程学院,江苏南京210096 [2]皖西学院生物与制药工程学院,安徽六安237012

出　　处：《药学进展》2021年第4期290-304,共15页Progress in Pharmaceutical Sciences

基　　金：国家重点研发计划项目(No.2017YFA0104300);国家自然科学基金重点项目(No.51832001);安徽省自然科学基金项目(No.1808085QH233)。

摘　　要：载药脂质微泡是由脂质壳膜和气核组成的负载治疗药物的多功能微气泡,具有高度的生物兼容性,能够增强超声显影并能进行智能药物递送,目前在超声造影剂和超声响应药物输送系统研究领域受到广泛的关注,并且正在被开发用于更多新的诊断和治疗应用。综述载药脂质微泡的结构特点、载药方法以及推进智能化超声医学技术的研究进展,并对其在超声医学技术上的应用做了总结和展望。Composed of lipid shell membrane and gas nucleus,drug-loaded lipid microbubbles are multi-functional microbubbles loaded with therapeutic drugs.They can be used to enhance ultrasound imaging and intelligent drug delivery due to their high biocompatibility.At present,drug-loaded lipip microbubbles have been widely used as ultrasound contrast agents and ultrasound response drug delivery system.In the near future,they are going to be developed for new diagnostic and therapeutic applications.In this review,the structural characteristics and preparation methods of drug-loaded lipid microbubbles and the research progress of intelligent ultrasonic medical technology are systematically summarized,and their application prospects in ultrasonic medical technology are discussed.

关 键 词：脂质微泡 超声医学技术 诊断和治疗 药物输送系统 

分 类 号：R730.5[医药卫生—肿瘤]