阿托伐他汀治疗动脉粥样硬化患者血浆β淀粉样蛋白水平的研究  

Study on the level of plasma amyloid-βprotein in patients with atherosclerosis treated with atorvastatin

作　　者：张严 商苏杭 高玲 魏珊 弥婉军 屈秋民[1] Zhang Yan;Shang Suhang;Gao Ling;Wei Shan;Mi Wanjun;Qu Qiumin(Department of Neurology,the First Affiliated Hospital of Xi’an Jiaotong University,Shaanxi 710061,China)

机构地区：[1]西安交通大学第一附属医院神经内科,陕西710061 [2]西安交通大学 [3]宝鸡市中医医院脑病二科

出　　处：《脑与神经疾病杂志》2021年第5期303-308,共6页Journal of Brain and Nervous Diseases

基　　金：陕西省重点研发计划项目(2018ZDXM-SF-052);心血管健康(苏州工业园区)研究院—中国心血管健康联盟血脂异常及动脉粥样硬化研究基金(MSD-2017002)。

摘　　要：目的探讨阿托伐他汀与动脉粥样硬化患者血浆β淀粉样蛋白(amyloid-βprotein,Aβ)水平的关系。方法2017年3月至2018年2月在西安交通大学第一附属医院神经内科住院的颈动脉粥样硬化患者,排除急性脑梗死、痴呆等可能影响血浆Aβ水平的因素,收集患者临床资料、既往疾病史、服药情况、肝肾功能等信息,晨空腹采集肘静脉血,ELISA测定血浆Aβ_(40)及Aβ_(42)浓度,分析阿托伐他汀与血浆Aβ水平的关系。结果共入组207例颈动脉粥样硬化患者,其中持续服用阿托伐他汀1个月以上100例,未服用他汀类药物107例,两组血浆Aβ_(40)水平(160.35±59.95:166.78±65.16 pg·mL^(-1),P=0.460)、Aβ_(42)水平(95.26±26.71:94.09±26.90 pg·mL^(-1),P=0.753)及Aβ_(40)/Aβ_(42)比值(1.69±0.45:1.78±0.56,P=0.202),两组比较均P>0.05。多因素分析校正可能的影响因素,血浆Aβ_(40)、Aβ_(42)水平及Aβ_(40)/Aβ_(42)比值与阿托伐他汀及服用时间、剂量无显著相关。结论未发现阿托伐他汀与动脉粥样硬化患者血浆Aβ水平的关系。Objective To explore the relationship between atorvastatin and plasma levels of amyloid-βprotein(Aβ)in patients with atherosclerosis.Method Patients with carotid atherosclerosis were enrolled from the Department of Neurology,the first affiliated Hospital of Xi’an Jiaotong University between March 2017 and February2018.Patients with acute cerebral infarction,dementia and other factors that may affect plasma Aβlevel were excluded.Clinical data,past disease history,medication status,liver and kidney function and other information were collected.Fasting blood samples were collected from every participant,and concentrations of plasma Aβ_(40) and Aβ_(42)were tested by ELISA.The relationship between atorvastatin and plasma Aβlevels was analyzed.Results A total of 207 patients were enrolled,including 100 atorvastatin users and 107 atorvastatin non-user.The univariate analysis showed that the levels of plasma Aβwere not significant different between atorvastatin users and non-users(Aβ_(40):160.35±59.9 vs.166.78±65.16 pg·mL^(-1),P=0.460;Aβ_(42):95.26±26.71 vs.94.09±26.90 pg·mL^(-1),P=0.753;Aβ_(40)/Aβ_(42) ratio:1.69±0.45 vs.1.78±0.56,P=0.202).After multivariable adjustment in the regression model,plasma Aβ_(40),Aβ_(42) and Aβ_(40)/Aβ_(42) ratio were not significantly correlated with atorvastatin,as well as the dose and duration of atorvastatin use.Conclusion No correlation was found between atorvastatin and levels of plasma Aβin patients with atherosclerosis.

关 键 词：阿托伐他汀 血浆Aβ 动脉粥样硬化 阿尔茨海默病 

分 类 号：R743.34[医药卫生—神经病学与精神病学]