利奈唑胺联合头孢曲松对GBS感染所致化脓性脑膜炎患儿脑脊液NSE、BMP、hs-CRP表达水平的影响  

Effect of linezolid combined with ceftriaxone on the cerebrospinal fluid NSE,BMP and hs-CRP expression levels of purulent meningitis children induced by GBS infection

作　　者：郑丽娇[1] 刘波 何丽[1] ZHENG Li-jiao;LIU Bo;HE Li(Department of Infection,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054;Department of Blood Transfusion,Xinjiang Occupational Disease Hospital,Urumqi,Xinjiang 830054)

机构地区：[1]新疆医科大学第一附属医院感染一科,新疆乌鲁木齐830054 [2]新疆职业病医院输血科,新疆乌鲁木齐830054

出　　处：《热带医学杂志》2021年第4期512-515,共4页Journal of Tropical Medicine

基　　金：新疆医科大学人文社会科学基金(2017XYFG91)。

摘　　要：目的探究利奈唑胺联合头孢曲松对B族链球菌(GBS)感染所致化脓性脑膜炎患儿脑脊液神经特异性烯醇化酶(NSE)、髓鞘碱性蛋白(BMP)、高敏感性C反应蛋白(hs-CRP)表达水平的影响。方法选取2016年1月-2019年1月新疆医科大学第一附属医院收治的88例GBS感染所致化脓性脑膜炎患儿,随机分为对照组和观察组,每组44例。对照组给予头孢曲松治疗,观察组在对照组的基础上联合利奈唑胺治疗,两组均连续治疗4周,治疗后定期随访6个月。比较治疗前后两组患儿脑脊液NSE、BMP、hs-CRP水平及其他生化指标水平,以及治疗后两组患儿临床症状改善情况及住院时间,统计随访期间两组患儿相关不良反应发生情况。结果与对照组比较,治疗后观察组患儿体温下降时间、颅内压下降时间、脑脊液白细胞计数(WBC)恢复正常时间及住院时间均显著缩短,脑脊液蛋白浓度与WBC显著降低,糖浓度显著升高(P<0.05);与治疗前比较,治疗后两组患儿脑脊液NSE、BMP及hsCRP水平显著降低,且观察组显著低于对照组(P<0.05)。观察组患儿并发症发生率(0.00%)显著低于对照组(13.64%),差异有统计学意义(P<0.05)。结论利奈唑胺联合头孢曲松可有效改善GBS感染所致化脓性脑膜炎患儿临床症状,降低脑脊液NSE、BMP及hs-CRP水平,安全性较高,且疗效优于头孢曲松单用。Objective To explore the effect of linezolid combined with ceftriaxone on the cerebrospinal fluid neurospecific enolase(NSE),myelin basic protein(BMP)and high sensitivity c-reactive protein(hs-CRP)expression levels of purulent meningitis children induced by group B Streptococcus(GBS)infection.Methods 88 cases purulent meningitis children induced by GBS in the First Affiliated Hospital of Xinjiang Medical University from Jan.2016 to Jan.2019 were selected and divided randomly into control group and observation group,44 cases of each group.Children in control group were treated with ceftriaxone,children in observation group were treated on the basis of control group combined with linezolid;two groups were treated for continuous 4 weeks,and regularly followed-up for 6 months after treatment.The clinical symptoms improved and the hospitalized time of children in two groups were compared;the cerebrospinal fluid NSE,BMP,hs-CRP levels and other biochemical indicators of children in two groups were detected and compared before and after the treatment;the related adverse reactions occurrence of children in two groups were analyzed during the following-up.Results Compared with control group,the times of hypothermia and intracranial pressure decreased,cerebrospinal fluid white blood cell count(WBC)returned to normal and hospitalized of children in observation group shortened.After treatment,the cerebrospinal fluid protein concentration and WBC decreased,sugar concentration increased significantly(P<0.05);the cerebrospinal fluid NSE,BMP and hs-CRP levels of children in two groups decreased,and those of the observation group was lower than those of control group after treatment(P<0.05).During the following-up period,the complications occurrence rate in observation group(0.00%)was significantly lower than the control group(13.64%)(P<0.05).Conclusion Linezolid combined with ceftriaxone could improve the clinical symptoms of purulent meningitis children induced by GBS,reduce the cerebrospinal fluid NSE,BMP and hs-CRP levels,and

关 键 词：B族链球菌 化脓性脑膜炎 利奈唑胺 头孢曲松 脑脊液 

分 类 号：R742.9[医药卫生—神经病学与精神病学]