Northern pig-tailed macaques(Macaca leonina)infected with SARS-CoV-2 show rapid viral clearance and persistent immune response  

作　　者：Tian-Zhang Song Hong-Yi Zheng Jian-Bao Han Xiao-Li Feng Feng-Liang Liu Xiang Yang Lin Jin Rong-Hua Luo Ren-Rong Tian Chao Liu Ming-Hua Li Hou-Rong Cai Yong-Tang Zheng 

机构地区：[1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province,KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China [2]Kunming National High-Level Biosafety Research Center for Non-Human Primates,Center for Biosafety Mega-Science,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650107,China [3]National Resource Center for Non-Human Primates,and National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility),Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650107,China [4]Department of Respiratory and Critical Care Medicine,Affiliated Drum Tower Hospital of Nanjing University,Nanjing,Jiangsu 210008,China

出　　处：《Zoological Research》2021年第3期350-353,共4页动物学研究（英文）

基　　金：This work was partly supported by the National Key R&D Program of China(2020YFC0842000);National Science and Technology Major Projects of Infectious Disease Funds(2017ZX10304402,2018ZX10301406-003);the National Natural Science Foundation of China(U1802284,U1902210);National Resource Center for Non-Human Primates。

摘　　要：Coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2),has become an unprecedented global health emergency.At present,SARS-CoV-2-infected nonhuman primates are considered the gold standard animal model for COVID-19 research.Here,we showed that northern pig-tailed macaques(Macaca leonina,NPMs)supported SARS-CoV-2 replication.Furthermore,compared with rhesus macaques,NPMs showed rapid viral clearance in lung tissues,nose swabs,throat swabs,and rectal swabs,which may be due to higher expression of interferon(IFN)-αin lung tissue.However,the rapid viral clearance was not associated with good outcome.In the second week post infection,NPMs developed persistent or even more severe inflammation and body injury compared with rhesus macaques.These results suggest that viral clearance may have no relationship with COVID-19 progression and SARS-CoV-2-infected NPMs could be considered as a critically ill animal model in COVID-19 research.

关 键 词：INFECTED lung INTERFERON 

分 类 号：R563.1[医药卫生—呼吸系统] R-332[医药卫生—内科学]