^(18)F-PDG PET/CT检查对食管癌放射治疗疗效的评估价值  

Value of ^(18)F-PDG PET/CT in the Evaluation of Radiotherapy for Esophageal Cancer

作　　者：张会平 张军强 宋延峰[3] ZHANG Hui-ping;ZHANG Jun-qiang;SONG Yan-feng(Department of Medical Affairs,The First People's Hospital of Xianyang,Xianyang Shaanxi,712000)

机构地区：[1]陕西省咸阳市第一人民医院医务部,陕西咸阳712000 [2]延安大学咸阳医院医学影像诊断及介入治疗科,陕西咸阳712000 [3]陕西省延安市人民医院CT诊断科,陕西延安716000

出　　处：《医学临床研究》2021年第5期691-693,697,共4页Journal of Clinical Research

基　　金：陕西省咸阳市重点研发计划项目(编号:2019k02-124)。

摘　　要：【目的】探讨MF-脱氧葡萄糖-正电子发射计算机断层显像(^(18)F-PDG PET/CT)在食管癌复发、转移及放疗疗效评价中的应用价值。【方法】选取在咸阳市第一人民医院治疗的疑似食管癌复发、转移患者58例,均行18F-PDG PET/CT检查,并对确诊者进行放射治疗,分析不同疗效患者相关参数的差异。【结果】58例患者中39例确诊复发、转移,58例患者共103处待检病灶,共确定复发、转移灶59处;^(18)F-PDG PET/CT判断食管癌复发、转移的灵敏度、特异度、阳性预测值、阴性预测值和准确率分别为93.22%、77.27%、84.62%、89.47%和86.41%。经放疗后,完全缓解(CR)患者12例,部分缓解(PR)患者20例,无变化(NR)7例,总有效率为82.05%(32/39);CR患者放疗后平均标准摄取值(SUVavg)、最大标准摄取值(SUVmax)和葡萄糖转运蛋白质(Glutl)水平明显低于PR和NR患者(P<0.05),而PR和NR患者之间相比较差异均无显著性(P>0.05)。【结论】^(18)F-PDG PET/CT在判断食管癌患者复发、转移中有较好的应用价值,同时可为放疗疗效判断提供一定帮助。【Objective】To explore the value of ^(18)F deoxyglucose positron emission computed tomography(^(18)F-PDG PET/CT)in the evaluation of recurrence and metastasis of esophageal cancer and the efficacy of radiotherapy.【Methods】A total of 58 patients with suspected recurrence and metastasis of esophageal cancer in our hospital were selected,all of them underwent ^(18)F-PDG PET/CT examination,and the confirmed patients were treated with radiotherapy,and the differences of related parameters of patients with different curative effects were analyzed.【Results】of the 58 patients,39 cases were diagnosed with recurrence and metastasis.A total of 103 lesions were detected in 58 patients,and 59 were confirmed with recurrence and metastasis;the sensitivity,specificity,positive predictive value,negative predictive value and accuracy of ^(18)F-PDG PET/CT were 93.22%,77.27%,84.62%,89.47% and 86.41%,respectively.After radiotherapy,there were 12 patients with complete remission(CR),20 patients with partial remission(PR)and 7 patients with no change(NR),the total effective rate was 82.05%(32/39);the average standard uptake value(SUVavg),maximum standard uptake value(SUVmax)and glucose transporter protein(GLUT1)levels of Cr patients after radiotherapy were significantly lower than those of PR and NR patients(P<0.05),but there was no significant difference between PR and NR patients(P<0.05).【Conclusion】^(18)F-PDG PET/CT has a good application value in judging the recurrence and me-tastasis of esophageal cancer patients,and it can also improve the judgment of radiotherapy efficacy.

关 键 词：食管肿瘤/影像诊断 氟脱氧葡萄糖F18 体层摄影术 螺旋计算机 正电子发射断层显像术 

分 类 号：R735.1[医药卫生—肿瘤]