IgG、IgE、CA19-9单独或联合检测对自身免疫性胰腺炎的诊断价值分析  

Diagnostic Value of IgG,IgE and CA19-9 in Autoimmune Pancreatitis

作　　者：朱峰波[1] 杨莹[1] 李秋霞 ZHU Feng-bo;YANG Ying;LI Qiu-xia(The Fifth People's Hospital of,Jinan inan 250022)

机构地区：[1]山东省济南市第五人民医院消化内科,山东济南250022

出　　处：《医学临床研究》2021年第5期743-746,共4页Journal of Clinical Research

摘　　要：【目的】探讨自身免疫性胰腺炎(AIP)患者血清免疫球蛋白-4(IgG_(4))、IgE和糖链抗原19-9CCA19-9)水平变化情况,并评估其单独和联合检测对AIP的诊断价值。【方法】选择2016年1月至2020年6月本院收治的112例胰腺炎患者,其中急性胰腺炎54例(AP组)、慢性胰腺炎23例(CP组)、1型AIP患者35例(AIP组),并选择同期于本院健康体检的健康志愿者30例(对照组),比较各组研究对象血清(IgG_(1)、IgG_(2)、IgG_(3)、IgG_(4)、IgE、CA19-9水平,绘制受试者工作曲线检测IgG_(4)、IgE和CA19-9诊断AIP的敏感度和特异度。【结果】四组患者血清IgG_(1)、IgG_(2)、IgG_(3)水平比较,差异无统计学意义(P>0.05);四组患者血清IgG_(4)水平比较,差异有统计学意义(P<0.05),AP组、CP组和AIP组均高于对照组,AIP组高于AP组、CP组。四组血清IgG、CA19-9、IgE水平比较,差异均有统计学意义(P<0.05),其中AP组、CP组、AIP组血清IgG水平高于对照组,AIP组血清CA19-9、IgE水平高于AP组、CP组、对照组。绘制ROC曲线,结果显示,IgG_(4)、IgE和CA19-9联合检测的敏感度、特异度分别为87.3%、94.1%,高于各指标的单独检测的敏感度和特异度。【结论】IgG_(4)、IgE和CA11-9在AIP患者中的水平高于AP、CP患者,三者的联合检测可提高诊断AIP的敏感度和特异度。【Objective】To detect the levels of IgG,IgE and CA19-9 in patients with AIP,and to evaluate the diagnostic value of single and combined detection for AIP.【Methods】From January 2016 to June 2020,112 pa-tients with pancreatitis in our hospital were selected,including 54 patients with acute pancreatitis(AP group),23 patients with chronic pancreatitis(CP Group),35 patients with type 1 AIP(AIP group),and 30 healthy volunteers(control group)in our hospital during the same period,The sensitivity and specificity of IgG_(4),IgE and CA19-9 in the diagnosis of AIP were detected by drawing the receiver operating curve.[Results]There was no significant difference in serum IgG_(1),IgG_(2) and IgG_(3) levels among the four groups(P>0.05);The serum IgG_(4) levels of the four groups were significantly higher than those of the control group(P<10.05).There were significant differences in serum IgG,CA19-9 and IgE levels among the four groups(P<0.05).The serum IgG levels in the AP group,the CP Group and the AIP group were higher than those in the control group,and the Serum CA19-9 and IgE levels in the AIP group were higher than those in the AP group,the CP Group and the control group.ROC curve was drawn.The results showed that the sensitivity and specificity of combined detection of IgG_(4),IgE and CA19-9 were 87.3% and 94.1%respectively,which were higher than those of single detection of each index.【Conclusion】The levels of IgG_(4),IgE and CA19-9 in AIP patients were higher than those in AP and CP patients.The combined detection of the three can improve the sensitivity and specificity in the diagnosis of AIP.

关 键 词：胰腺炎/诊断 自身免疫疾病 免疫球蛋白G/分析 免疫球蛋白E/分析 CA-19-9抗原/分析 

分 类 号：R576.2[医药卫生—消化系统]