肿瘤免疫治疗的分子影像监测  

Molecular image monitoring of tumor immunotherapy

作　　者：郑雨婷 兰晓莉[1] 张永学[1] Zheng Yuting;Lan Xiaoli;Zhang Yongxue(Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Key Laboratory of Molecular Imaging of Hubei Province,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院核医学科,分子影像湖北省重点实验室,武汉430022

出　　处：《国际放射医学核医学杂志》2021年第3期176-181,共6页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金(81771863)。

摘　　要：使用检查点抑制剂的生物免疫疗法已发展成为一种有前途的癌症治疗方法,但免疫抑制剂治疗并非对所有患者都有效,而且还普遍存在严重的免疫相关不良反应。分子影像可以从分子和细胞水平识别肿瘤微环境中免疫检查点(IC)的表达,不仅有助于筛选出适合免疫疗法的患者,还可以监测肿瘤的治疗反应。笔者综述了分子影像在靶向肿瘤IC治疗监测方面的现状和最新进展。Biological immunotherapy using checkpoint inhibitors has evolved into a promising therapy for cancer patients.Unfortunately,not all patients respond to the therapy while severe immunerelated adverse effects are prevalent.Molecular imaging can detect the expression of immune checkpoint(IC)at the molecular and cellular level in tumor microenvironment.It can help in selecting patients who are suitable for immunotherapy,and also monitor the tumor response.This paper reviews the current status and latest progress of molecular imaging of IC targets.

关 键 词：肿瘤 分子影像 免疫治疗 免疫检查点 

分 类 号：R730.51[医药卫生—肿瘤]