咳嗽变异性哮喘病理机制及造模方法的研究进展  

Research Progress on the Pathological Mechanism and Modeling Methods of Cough Variant Asthma

作　　者：陈婷婷 易桂生[1] CHEN Tingting;YI Guisheng(Department of Respiratory Medicine,Affiliated Hospital of Guilin Medical College,Guilin 54100,China)

机构地区：[1]桂林医学院附属医院呼吸科,桂林541000

出　　处：《实验动物科学》2021年第2期74-78,共5页Laboratory Animal Science

基　　金：桂林市科学研究与技术开发计划项目No.20190128-5-7。

摘　　要：咳嗽变异性哮喘(cough variant asthma,CVA)是一种类型比较特殊的哮喘,慢性咳嗽的主要病因之一。目前,很多学者认为CVA是典型哮喘的前体疾病或是典型哮喘在气道炎症比较轻微状态下的一种过渡性表现,30%的CVA可能会演变成为典型哮喘。因此,CVA的早期发现、早期治疗就显得尤为重要,目前CVA发病机制尚不明确,深入研究已成为较为重要的方向,基于CVA模型的动物实验数目众多,但方法不尽相同,本文就咳嗽变异性哮喘的病理改变及近十年来造模方法的不同进行归纳综述。Cough variant asthma(CVA)is a special type of asthma,one of the main causes of chronic cough.At present,many scholars believe that CVA is a precursor disease of typical asthma or a transitional manifestation of typical asthma when airway inflammation is relatively mild.There is 30%of CVA may evolve into typical asthma.Therefore,early detection and early treatment of CVA are particularly important.At present,the pathogenesis of CVA is not clear.In-depth research has become a more important direction.There are many animal experiments based on CVA models,but the method are not the same.This article focuses on cough variation.The pathological changes of asthma and the different modeling method in the past ten years are summarized.

关 键 词：咳嗽变异型哮喘 病理生理机制 动物模型 研究进展 

分 类 号：R-33[医药卫生]