血液相关因子与老年高血压合并抑郁的相关性研究  

Study on the correlation between blood related factors and depression in elderly patients with hypertension

作　　者：杨宁波 胡红霞 李洁[3] 杨喜山[4] 张国秀[3] 刘松年[3] 胡莹莹[3] 孙文文 纪翠锋 YANG Ning-bo(Psychosocial department,the first affiliated hospital of Henan University of technology,Luoyang,Henan,471003,China)

机构地区：[1]河南科技大学第一附属医院精神心理科,河南洛阳471003 [2]河南科技大学第一附属医院医学检验科,河南洛阳471003 [3]河南科技大学第一附属医院全科医学科,河南洛阳471003 [4]河南科技大学第一附属医院心血管科,河南洛阳471003

出　　处：《齐齐哈尔医学院学报》2021年第8期659-662,共4页Journal of Qiqihar Medical University

基　　金：河南省高等学校重点科研项目(19B320008);河南省医学教育研究项目(Wjlx2018145)。

摘　　要：目的探索老年高血压患者血压高低、血液AngⅡ、Cor及Hcy含量与患者抑郁的关系。方法选择2018年6月—2020年6月本院收治的老年高血压患者164例作为研究对象,将单纯高血压患者89例作为对照组,将高血压合并抑郁患者75例作为观察组,比较两组患者血压高低,血液AngⅡ、8点Cor、16点Cor、Hcy及8点Cor/16点Cor,抑郁自评量表(SDS)评分。另外再按照患者不同血压分级进行分组比较上述指标的差异。结果对两组患者一般资料及临床特征比较后发现,观察组SDS评分明显高于对照组,差异有统计学意义(P<0.05),其余指标差异均无统计学意义(P>0.05);观察组24 h、晚上及白天的收缩压和舒张压均明显高于对照组,差异均有统计学意义(P<0.05);两组患者血液AngⅡ、8点Cor、16点Cor、Hcy及8点Cor/16点Cor水平比较,差异均有统计学意义(P<0.05);不同血压分级患者血液AngⅡ、8点Cor、16点Cor、Hcy及8点Cor/16点Cor水平比较,差异均有统计学意义(P<0.05)。结论老年高血压患者血压高低,血液AngⅡ、8点Cor、16点Cor、Hcy及8点Cor/16点Cor均与抑郁症的发生存在明显关系。Objective To explore the relationship between blood pressure,blood AngⅡ,Cor and Hcy levelsand depression in elderly patients with hypertension.Methods 164 elderly patients with hypertension admitted to our hospital from June 2018 to June 2020 were selected as the research object,89 patients with simple hypertension were selected as the control group,and 75 patients with hypertension and depression were selected as the observation group.The blood pressure,blood AngⅡ,Cor at 8 am and 16 pm,Hcy,Cor at 8 am/Cor at 16 pm,and self rating depression scale(SDS)scores were compared between the two groups.In addition,the patients were grouped according to the different blood pressure classification,the differences of the above indicators among different groups were compared.Results Comparisonof the general data and clinical characteristics of the two groupsfound that the SDS score of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05),and the differences of other indicators between the two groups were not statistically significant(P>0.05).The systolic and diastolic blood pressure in the observation group during 24 hours,at night and during the day were significantly higher than those in the control group,the differences were statistically significant(P<0.05).There were statistically significant differences inblood Ang II,Cor at 8 am and 16 pm,Hcy,Cor at 8 am/Cor at 16 pm between the tow groups(P<0.05).There were statistically significant differences inblood Ang II,Cor at 8 am and 16 pm,Hcy,Cor at 8 am/Cor at 16 pm among patients with different blood pressure(P<0.05).Conclusions Blood pressure,blood AngⅡ,Cor at 8 am and 16 pm,Hcy,Cor at 8 am/Cor at 16 pm were significantly related to the occurrence of depression in elderly patients with hypertension.

关 键 词：血液相关因子 老年高血压 抑郁 

分 类 号：R749.4[医药卫生—神经病学与精神病学]